C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: roundabout, axon guidance receptor, homolog 1 (Drosophila)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000169855 ROBO1 9606 - 3:78597240-79767815 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000436010 ROBO1-201 78597246-79019459 protein_coding
  ENST00000464233 ROBO1-001 78597241-79767815 protein_coding
  ENST00000466906 ROBO1-009 78600113-78607289 processed_transcript
  ENST00000467549 ROBO1-005 78598811-79018544 protein_coding
  ENST00000472273 ROBO1-007 78627407-78634580 protein_coding
  ENST00000484514 ROBO1-006 78659939-78715257 retained_intron
  ENST00000488735 ROBO1-012 78692888-78714520 retained_intron
  ENST00000492990 ROBO1-011 79512805-79589942 nonsense_mediated_decay
  ENST00000495273 ROBO1-003 78598688-79019015 protein_coding
  ENST00000495961 ROBO1-010 78667883-78670242 protein_coding
  ENST00000498428 ROBO1-004 78606808-78670540 retained_intron
  ENST00000618833 ROBO1-202 78597240-79019459 protein_coding
  ENST00000618846 ROBO1-203 78597246-79019459 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000436010ENST00000464233ENST00000466906ENST00000467549ENST00000495273ENST00000498428ENST00000618833ENST00000618846
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000436010 N/A N/A N/A 1.068±0.00 N/A N/A N/A N/A 0.121±0.00 N/A N/A N/A N/A N/A
ENST00000464233 N/A N/A N/A 1.757±0.00 N/A N/A N/A N/A 0.538±0.00 N/A 0.212±0.00 N/A N/A 1.487±0.00
ENST00000466906 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 6.556±0.00 16.208±0.00 32.761±0.00
ENST00000467549 1.378±0.00 2.926±0.00 0.700±0.00 N/A 1.341±0.25 2.258±0.00 0.418±0.22 N/A 1.635±0.00 1.079±0.27 0.468±0.18 1.116±0.35 1.014±0.79 3.250±0.27
ENST00000495273 2.324±0.00 N/A N/A 2.313±0.00 1.171±0.00 0.529±0.00 0.511±0.00 0.867±0.00 0.772±0.00 N/A N/A 2.087±1.15 0.214±0.00 3.945±0.00
ENST00000498428 N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.683±0.00 0.380±0.00 N/A N/A N/A
ENST00000618833 N/A 1.494±0.00 0.114±0.00 N/A 1.304±0.28 1.111±0.00 0.348±0.00 N/A 0.648±0.00 1.170±0.00 0.060±0.00 1.470±0.62 1.244±0.90 1.504±0.00
ENST00000618846 N/A N/A N/A 2.298±0.00 N/A 0.786±0.00 N/A N/A N/A N/A N/A N/A N/A N/A

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0002042 IMP cell migration involved in sprouting angiogenesis
GO:0005515 IEA protein binding
GO:0005737 IDA cytoplasm
GO:0005886 TAS plasma membrane
GO:0005887 TAS integral component of plasma membrane
GO:0006919 IMP activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007155 TAS cell adhesion
GO:0007156 IDA homophilic cell adhesion via plasma membrane adhesion molecules
GO:0007399 TAS nervous system development
GO:0007411 TAS axon guidance
GO:0008046 TAS axon guidance receptor activity
GO:0008285 IEA negative regulation of cell proliferation
GO:0009986 IDA cell surface
GO:0016199 ISS axon midline choice point recognition
GO:0021836 IDA chemorepulsion involved in postnatal olfactory bulb interneuron migration
GO:0030275 IPI LRR domain binding
GO:0030673 IEA axolemma
GO:0033600 IMP negative regulation of mammary gland epithelial cell proliferation
GO:0035385 IMP Roundabout signaling pathway
GO:0042802 IDA identical protein binding
GO:0050772 IDA positive regulation of axonogenesis
GO:0050925 IDA negative regulation of negative chemotaxis
GO:0060763 IEA mammary duct terminal end bud growth
GO:0070100 IMP negative regulation of chemokine-mediated signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000026784 robo1 roundabout homolog 1 protein_coding Danio_rerio
ENSMUSG00000022883 Robo1 roundabout homolog 1 (Drosophila) protein_coding Mus_musculus

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