C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: cyclin-dependent kinase 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000170312 CDK1 9606 + 10:60778331-60794852 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000316629 CDK1-201 60778454-60794843 protein_coding
  ENST00000373809 CDK1-008 60780153-60794852 protein_coding
  ENST00000395284 CDK1-007 60778454-60794852 protein_coding
  ENST00000448257 CDK1-009 60778493-60794828 protein_coding
  ENST00000475504 CDK1-010 60778365-60787069 retained_intron
  ENST00000487784 CDK1-012 60787671-60791927 retained_intron
  ENST00000519078 CDK1-013 60778331-60791969 protein_coding
  ENST00000519760 CDK1-014 60778457-60783593 processed_transcript
  ENST00000613147 CDK1-202 60778454-60794843 protein_coding
  ENST00000614696 CDK1-203 60778496-60794843 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000316629ENST00000373809ENST00000395284ENST00000448257ENST00000475504ENST00000519078ENST00000613147ENST00000614696
Transcript ID Adipose Adrenal Bladder Brain Breast Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000316629 N/A N/A N/A N/A N/A N/A 0.298±0.00 0.423±0.00 N/A N/A 5.438±0.00 2.383±0.00 4.751±0.00
ENST00000373809 N/A N/A N/A N/A 0.249±0.00 0.367±0.00 0.589±0.00 0.071±0.00 N/A 0.122±0.00 23.952±0.00 2.824±0.00 4.977±0.00
ENST00000395284 N/A 0.596±0.00 N/A N/A 1.590±0.74 N/A N/A N/A 1.396±0.00 N/A 9.191±0.30 2.796±0.08 9.434±0.00
ENST00000448257 0.952±0.00 N/A N/A N/A N/A N/A 0.924±0.00 N/A N/A N/A N/A N/A N/A
ENST00000475504 N/A N/A N/A N/A 1.105±0.00 N/A N/A N/A 0.360±0.00 N/A N/A N/A N/A
ENST00000519078 0.903±0.00 N/A 0.084±0.00 0.485±0.00 N/A N/A N/A 0.330±0.07 N/A N/A N/A N/A N/A
ENST00000613147 N/A 0.263±0.00 N/A 0.250±0.00 N/A 0.130±0.00 N/A N/A N/A N/A N/A N/A N/A
ENST00000614696 N/A N/A N/A 0.220±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0000GY CIL_0000GY_0002 CGP 10:60026298-60794852

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000082 TAS G1/S transition of mitotic cell cycle
GO:0000083 TAS regulation of transcription involved in G1/S transition of mitotic cell cycle
GO:0000086 TAS G2/M transition of mitotic cell cycle
GO:0000165 TAS MAPK cascade
GO:0000186 TAS activation of MAPKK activity
GO:0000187 TAS activation of MAPK activity
GO:0000226 TAS microtubule cytoskeleton organization
GO:0000278 TAS mitotic cell cycle
GO:0002224 TAS toll-like receptor signaling pathway
GO:0002755 TAS MyD88-dependent toll-like receptor signaling pathway
GO:0002756 TAS MyD88-independent toll-like receptor signaling pathway
GO:0004672 NAS:IEA protein kinase activity
GO:0004674 IDA protein serine/threonine kinase activity
GO:0004693 IDA cyclin-dependent protein serine/threonine kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005634 IDA nucleus
GO:0005654 TAS nucleoplasm
GO:0005737 IDA cytoplasm
GO:0005739 TAS mitochondrion
GO:0005813 IDA centrosome
GO:0005829 TAS cytosol
GO:0005876 IDA spindle microtubule
GO:0006260 TAS DNA replication
GO:0006281 TAS DNA repair
GO:0006461 IEA protein complex assembly
GO:0006468 IEA protein phosphorylation
GO:0006915 IEA apoptotic process
GO:0007067 IEA mitotic nuclear division
GO:0007077 TAS mitotic nuclear envelope disassembly
GO:0007095 IEA mitotic G2 DNA damage checkpoint
GO:0007098 TAS centrosome cycle
GO:0007173 TAS epidermal growth factor receptor signaling pathway
GO:0007264 TAS small GTPase mediated signal transduction
GO:0007265 TAS Ras protein signal transduction
GO:0007344 TAS pronuclear fusion
GO:0007411 TAS axon guidance
GO:0007569 IEA cell aging
GO:0008286 TAS insulin receptor signaling pathway
GO:0008353 IDA RNA polymerase II carboxy-terminal domain kinase activity
GO:0008543 TAS fibroblast growth factor receptor signaling pathway
GO:0009636 IEA response to toxic substance
GO:0010243 IEA response to organonitrogen compound
GO:0010628 IEA positive regulation of gene expression
GO:0014038 TAS regulation of Schwann cell differentiation
GO:0014070 IEA response to organic cyclic compound
GO:0014075 IEA response to amine
GO:0014823 IEA response to activity
GO:0016020 IDA membrane
GO:0016301 IEA kinase activity
GO:0016477 TAS cell migration
GO:0016572 IEA histone phosphorylation
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0018105 IDA peptidyl-serine phosphorylation
GO:0018107 IDA peptidyl-threonine phosphorylation
GO:0030261 IEA chromosome condensation
GO:0030332 IEA cyclin binding
GO:0030496 IDA midbody
GO:0030544 IEA Hsp70 protein binding
GO:0030855 IEP epithelial cell differentiation
GO:0031100 IEA organ regeneration
GO:0031145 TAS anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0033160 IEA positive regulation of protein import into nucleus, translocation
GO:0034134 TAS toll-like receptor 2 signaling pathway
GO:0034138 TAS toll-like receptor 3 signaling pathway
GO:0034142 TAS toll-like receptor 4 signaling pathway
GO:0034146 TAS toll-like receptor 5 signaling pathway
GO:0034162 TAS toll-like receptor 9 signaling pathway
GO:0034166 TAS toll-like receptor 10 signaling pathway
GO:0034501 IDA protein localization to kinetochore
GO:0035173 IEA histone kinase activity
GO:0035666 TAS TRIF-dependent toll-like receptor signaling pathway
GO:0038095 TAS Fc-epsilon receptor signaling pathway
GO:0038123 TAS toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124 TAS toll-like receptor TLR6:TLR2 signaling pathway
GO:0042493 IEA response to drug
GO:0042542 IEA response to hydrogen peroxide
GO:0043066 IDA negative regulation of apoptotic process
GO:0045087 TAS innate immune response
GO:0045471 IEA response to ethanol
GO:0045740 IEA positive regulation of DNA replication
GO:0045931 IEA positive regulation of mitotic cell cycle
GO:0045995 TAS regulation of embryonic development
GO:0046686 IEA response to cadmium ion
GO:0046688 IEA response to copper ion
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0048678 IEA response to axon injury
GO:0051403 TAS stress-activated MAPK cascade
GO:0051437 TAS positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051439 TAS regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0055015 IEA ventricular cardiac muscle cell development
GO:0060045 IEA positive regulation of cardiac muscle cell proliferation
GO:0070062 IDA extracellular vesicular exosome
GO:0070301 IEA cellular response to hydrogen peroxide
GO:0072686 IDA mitotic spindle

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000087554 cdk1 cyclin-dependent kinase 1 protein_coding Danio_rerio
ENSMUSG00000019942 Cdk1 cyclin-dependent kinase 1 protein_coding Mus_musculus

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