C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: adenosine A2b receptor
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000170425 ADORA2B 9606 + 17:15944917-15975746 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000304222 ADORA2B-001 15944917-15975746 protein_coding
  ENST00000582124 ADORA2B-002 15973863-15975737 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000304222ENST00000582124
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000304222 N/A 0.148±0.00 0.627±0.00 1.736±0.15 0.543±0.02 2.605±1.43 0.173±0.10 N/A 0.575±0.00 1.630±1.42 N/A 1.852±0.41 3.933±2.57 N/A
ENST00000582124 0.039±0.00 0.561±0.00 0.097±0.00 0.130±0.00 0.059±0.00 0.258±0.12 0.333±0.00 0.508±0.23 0.242±0.03 0.333±0.00 0.239±0.00 0.828±0.08 N/A 0.557±0.01

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0002XH CIL_0002XH_0001 CGP 17:15944917-15999717

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000187 TAS activation of MAPK activity
GO:0001609 IEA G-protein coupled adenosine receptor activity
GO:0001973 IEA adenosine receptor signaling pathway
GO:0002882 IEA positive regulation of chronic inflammatory response to non-antigenic stimulus
GO:0004930 IEA G-protein coupled receptor activity
GO:0005886 TAS plasma membrane
GO:0005887 TAS integral component of plasma membrane
GO:0006968 TAS cellular defense response
GO:0007186 TAS:IEA G-protein coupled receptor signaling pathway
GO:0007189 IEA adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007190 TAS activation of adenylate cyclase activity
GO:0007254 TAS JNK cascade
GO:0007588 TAS excretion
GO:0010575 IEA positive regulation vascular endothelial growth factor production
GO:0016021 IEA integral component of membrane
GO:0030819 IEA positive regulation of cAMP biosynthetic process
GO:0030828 IEA positive regulation of cGMP biosynthetic process
GO:0031284 IEA positive regulation of guanylate cyclase activity
GO:0031668 IEA cellular response to extracellular stimulus
GO:0032722 IEA positive regulation of chemokine production
GO:0032755 IEA positive regulation of interleukin-6 production
GO:0043306 IEA positive regulation of mast cell degranulation
GO:0060087 IEA relaxation of vascular smooth muscle

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000002533 adora2b adenosine A2b receptor protein_coding Danio_rerio
ENSMUSG00000018500 Adora2b adenosine A2b receptor protein_coding Mus_musculus

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