C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: prostaglandin E receptor 4 (subtype EP4)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000171522 PTGER4 9606 + 5:40679498-40693735 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000302472 PTGER4-001 40679498-40693735 protein_coding
  ENST00000509543 PTGER4-005 40681687-40685451 processed_transcript
  ENST00000512578 PTGER4-004 40681490-40691967 processed_transcript
  ENST00000513635 PTGER4-002 40681702-40692043 processed_transcript
  ENST00000514343 PTGER4-003 40679930-40681680 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000302472ENST00000509543ENST00000512578ENST00000514343
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000302472 N/A 4.421±0.00 N/A 0.220±0.20 7.287±0.57 3.514±2.70 1.135±0.75 7.134±0.00 0.826±0.42 2.797±0.00 1.125±0.19 0.576±0.26 0.842±0.40 1.601±0.00
ENST00000509543 N/A N/A N/A N/A N/A N/A N/A 3.590±0.00 N/A N/A N/A N/A N/A N/A
ENST00000512578 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 1.031±0.00 N/A
ENST00000514343 4.101±0.00 N/A 1.303±0.00 N/A N/A N/A 0.429±0.00 N/A N/A 14.288±0.00 N/A N/A 0.595±0.18 2.091±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0006MD CIL_0006MD_0002 CGP 5:40679498-40755975

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004930 IEA G-protein coupled receptor activity
GO:0004957 IDA prostaglandin E receptor activity
GO:0005515 IPI protein binding
GO:0005886 TAS plasma membrane
GO:0006955 IEP immune response
GO:0007186 IEA G-protein coupled receptor signaling pathway
GO:0007188 IDA adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0007254 ISS JNK cascade
GO:0009612 IEP response to mechanical stimulus
GO:0016021 NAS:IEA integral component of membrane
GO:0030278 IEA regulation of ossification
GO:0032496 IEA response to lipopolysaccharide
GO:0033624 IDA negative regulation of integrin activation
GO:0042093 ISS T-helper cell differentiation
GO:0050710 ISS negative regulation of cytokine secretion
GO:0050715 ISS positive regulation of cytokine secretion
GO:0050728 IDA negative regulation of inflammatory response
GO:0050729 ISS positive regulation of inflammatory response
GO:0051492 ISS regulation of stress fiber assembly
GO:0060348 ISS bone development
GO:0070371 ISS ERK1 and ERK2 cascade
GO:0071260 ISS cellular response to mechanical stimulus
GO:2000420 IDA negative regulation of eosinophil extravasation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000035415 ptger4b prostaglandin E receptor 4 (subtype EP4) b protein_coding Danio_rerio
ENSDARG00000059236 ptger4a prostaglandin E receptor 4 (subtype EP4) a protein_coding Danio_rerio
ENSMUSG00000039942 Ptger4 prostaglandin E receptor 4 (subtype EP4) protein_coding Mus_musculus

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