C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: RAS guanyl releasing protein 4
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000171777 RASGRP4 9606 - 19:38409051-38426305 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000293062 RASGRP4-201 38409059-38426305 protein_coding
  ENST00000426920 RASGRP4-202 38409059-38426305 protein_coding
  ENST00000433821 RASGRP4-203 38409059-38426305 protein_coding
  ENST00000454404 RASGRP4-005 38409058-38426305 protein_coding
  ENST00000586305 RASGRP4-012 38409055-38426187 protein_coding
  ENST00000587287 RASGRP4-015 38409115-38411396 retained_intron
  ENST00000587738 RASGRP4-013 38409840-38426162 protein_coding
  ENST00000587753 RASGRP4-006 38409058-38426305 protein_coding
  ENST00000588404 RASGRP4-007 38409058-38426305 retained_intron
  ENST00000588708 RASGRP4-014 38409057-38417147 retained_intron
  ENST00000589100 RASGRP4-011 38412415-38426197 retained_intron
  ENST00000589358 RASGRP4-002 38409058-38426305 nonsense_mediated_decay
  ENST00000589474 RASGRP4-001 38409058-38426305 nonsense_mediated_decay
  ENST00000592322 RASGRP4-008 38409058-38426305 retained_intron
  ENST00000614135 RASGRP4-009 38409058-38426305 protein_coding
  ENST00000615340 RASGRP4-010 38409051-38426197 retained_intron
  ENST00000615439 RASGRP4-204 38409059-38426305 protein_coding
  ENST00000617966 RASGRP4-003 38409058-38426305 protein_coding
  ENST00000618320 RASGRP4-205 38409058-38426305 protein_coding
  ENST00000622174 RASGRP4-004 38409058-38426305 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBreastColonHeartLiverLungMusclePlacentaTestisENST00000426920ENST00000454404ENST00000586305ENST00000587738ENST00000587753ENST00000588708ENST00000589100ENST00000614135ENST00000615340ENST00000615439ENST00000622174
Transcript ID Adipose Adrenal Bladder Breast Colon Heart Liver Lung Muscle Placenta Testis
ENST00000426920 N/A N/A N/A N/A N/A N/A 0.121±0.00 0.222±0.00 N/A N/A N/A
ENST00000454404 N/A N/A N/A N/A N/A N/A N/A 1.381±0.00 N/A 1.391±0.00 N/A
ENST00000586305 N/A N/A N/A N/A N/A N/A N/A N/A 0.349±0.00 N/A N/A
ENST00000587738 1.462±0.00 N/A N/A N/A N/A N/A N/A N/A N/A 1.434±0.00 N/A
ENST00000587753 N/A N/A N/A N/A N/A N/A N/A N/A N/A 1.832±0.19 N/A
ENST00000588708 1.081±0.00 1.173±0.00 N/A 0.522±0.32 0.185±0.00 N/A N/A 0.989±0.51 0.229±0.00 1.339±0.00 1.067±0.00
ENST00000589100 N/A N/A N/A N/A N/A N/A N/A 0.213±0.00 N/A N/A N/A
ENST00000614135 N/A N/A N/A N/A N/A N/A N/A N/A N/A 1.514±0.00 N/A
ENST00000615340 N/A N/A 0.052±0.00 N/A N/A 0.115±0.00 N/A N/A N/A N/A N/A
ENST00000615439 N/A N/A N/A 0.622±0.00 N/A N/A N/A N/A N/A N/A N/A
ENST00000622174 N/A N/A N/A N/A N/A N/A 0.108±0.00 0.215±0.00 N/A N/A N/A

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0005085 IEA guanyl-nucleotide exchange factor activity
GO:0005088 IDA Ras guanyl-nucleotide exchange factor activity
GO:0005509 IEA calcium ion binding
GO:0005622 IEA intracellular
GO:0005737 IEA cytoplasm
GO:0005886 TAS plasma membrane
GO:0007169 NAS transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007202 NAS activation of phospholipase C activity
GO:0007264 IEA small GTPase mediated signal transduction
GO:0008277 NAS regulation of G-protein coupled receptor protein signaling pathway
GO:0008283 IDA cell proliferation
GO:0009991 IDA response to extracellular stimulus
GO:0016020 IDA membrane
GO:0016049 IDA cell growth
GO:0019992 TAS diacylglycerol binding
GO:0030099 TAS myeloid cell differentiation
GO:0030742 NAS GTP-dependent protein binding
GO:0032320 IDA positive regulation of Ras GTPase activity
GO:0035556 IEA intracellular signal transduction
GO:0046579 IDA positive regulation of Ras protein signal transduction
GO:0051056 IEA regulation of small GTPase mediated signal transduction

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000061796 rasgrp4 RAS guanyl releasing protein 4 protein_coding Danio_rerio
ENSMUSG00000030589 Rasgrp4 RAS guanyl releasing protein 4 protein_coding Mus_musculus

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