C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: phosphodiesterase 3A, cGMP-inhibited
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000172572 PDE3A 9606 + 12:20369245-20684381 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000359062 PDE3A-001 20369245-20684381 protein_coding
  ENST00000542675 PDE3A-003 20370125-20557224 retained_intron
  ENST00000544307 PDE3A-002 20571864-20680517 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000359062ENST00000544307
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000359062 2.673±0.00 3.911±0.00 1.604±0.00 0.597±0.00 1.774±0.05 5.817±1.76 24.872±5.58 1.061±0.64 1.449±1.14 4.264±0.00 0.721±0.00 0.731±0.53 3.734±0.90 0.791±0.54
ENST00000544307 N/A N/A N/A N/A N/A N/A N/A 0.182±0.00 N/A N/A 0.407±0.00 N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007ZU CIL_0007ZU_0001 VISTA 12:20114532-20715290
CIL_0005FM CIL_0005FM_0001 CGP 12:20369245-20753386

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001556 IEA oocyte maturation
GO:0004114 IEA 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0004115 IEA 3',5'-cyclic-AMP phosphodiesterase activity
GO:0004119 IEA cGMP-inhibited cyclic-nucleotide phosphodiesterase activity
GO:0005829 TAS cytosol
GO:0006198 IDA cAMP catabolic process
GO:0006629 TAS lipid metabolic process
GO:0007165 IEA signal transduction
GO:0007596 TAS blood coagulation
GO:0016021 IEA integral component of membrane
GO:0016101 IEA diterpenoid metabolic process
GO:0019933 IMP cAMP-mediated signaling
GO:0019934 IMP cGMP-mediated signaling
GO:0030552 IEA cAMP binding
GO:0040020 IEA regulation of meiosis
GO:0042493 IEA response to drug
GO:0043066 IEA negative regulation of apoptotic process
GO:0043116 IMP negative regulation of vascular permeability
GO:0043117 IMP positive regulation of vascular permeability
GO:0046872 IEA metal ion binding
GO:0051591 IEA response to cAMP
GO:0060282 IEA positive regulation of oocyte development
GO:0071321 IDA cellular response to cGMP
GO:0071560 IEP cellular response to transforming growth factor beta stimulus

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000004227 pde3a phosphodiesterase 3A, cGMP-inhibited protein_coding Danio_rerio
ENSMUSG00000041741 Pde3a phosphodiesterase 3A, cGMP inhibited protein_coding Mus_musculus

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