C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: phosphodiesterase 3A, cGMP inhibited
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000041741 Pde3a 10090 + 6:141249269-141505940 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000043259 Pde3a-001 141249269-141505940 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000043259
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000043259 2.903±1.49 1.859±0.58 2.106±0.51 0.434±0.16 1.192±0.42 5.863±2.32 5.165±0.57 1.534±0.20 0.314±0.14 8.249±1.43 0.263±0.10 2.308±1.03 0.960±0.45 0.078±0.03

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007ZU CIL_0007ZU_0002 VISTA 6:140994807-141595982
CIL_0005FM CIL_0005FM_0002 CGP 6:141249269-141570177

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001556 IDA oocyte maturation
GO:0004115 IDA 3',5'-cyclic-AMP phosphodiesterase activity
GO:0004119 IEA cGMP-inhibited cyclic-nucleotide phosphodiesterase activity
GO:0005829 IEA cytosol
GO:0006198 IEA cAMP catabolic process
GO:0016021 IEA integral component of membrane
GO:0016101 IEA diterpenoid metabolic process
GO:0019933 IEA cAMP-mediated signaling
GO:0019934 IEA cGMP-mediated signaling
GO:0030552 IEA cAMP binding
GO:0040020 IDA regulation of meiosis
GO:0042493 IDA response to drug
GO:0043066 IEA negative regulation of apoptotic process
GO:0043116 IEA negative regulation of vascular permeability
GO:0043117 IEA positive regulation of vascular permeability
GO:0046872 IEA metal ion binding
GO:0051591 IEA response to cAMP
GO:0060282 IGI positive regulation of oocyte development
GO:0071321 IEA cellular response to cGMP
GO:0071560 IEA cellular response to transforming growth factor beta stimulus

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000004227 pde3a phosphodiesterase 3A, cGMP-inhibited protein_coding Danio_rerio
ENSG00000172572 PDE3A phosphodiesterase 3A, cGMP-inhibited protein_coding Homo_sapiens

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