C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: adrenergic, beta, receptor kinase 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000173020 ADRBK1 9606 + 11:67266410-67286556 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000308595 ADRBK1-001 67266410-67286556 protein_coding
  ENST00000416281 ADRBK1-002 67276537-67286555 retained_intron
  ENST00000524899 ADRBK1-007 67284271-67285591 processed_transcript
  ENST00000526285 ADRBK1-011 67266481-67286536 protein_coding
  ENST00000526572 ADRBK1-014 67281684-67283959 retained_intron
  ENST00000527176 ADRBK1-008 67281876-67285137 processed_transcript
  ENST00000529738 ADRBK1-004 67279474-67286372 processed_transcript
  ENST00000529815 ADRBK1-012 67282125-67283231 retained_intron
  ENST00000530291 ADRBK1-010 67270938-67279519 processed_transcript
  ENST00000531390 ADRBK1-005 67282781-67284171 retained_intron
  ENST00000532099 ADRBK1-006 67281509-67284369 processed_transcript
  ENST00000532611 ADRBK1-009 67283175-67284323 retained_intron
  ENST00000533077 ADRBK1-003 67280194-67284622 retained_intron
  ENST00000534651 ADRBK1-013 67281459-67282066 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000308595ENST00000416281ENST00000526285ENST00000526572ENST00000527176ENST00000530291
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000308595 21.250±0.00 66.660±0.00 1.260±0.00 21.695±12.44 12.053±6.43 13.755±10.01 9.844±8.88 11.481±10.02 7.183±5.16 17.439±13.13 12.104±8.91 26.583±12.72 25.976±4.02 14.755±4.28
ENST00000416281 N/A N/A N/A N/A 1.439±0.00 1.433±0.00 N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000526285 N/A N/A N/A N/A N/A N/A N/A 2.030±0.00 N/A N/A N/A N/A N/A N/A
ENST00000526572 N/A N/A N/A N/A N/A N/A 1.451±0.00 N/A N/A N/A N/A N/A N/A N/A
ENST00000527176 N/A N/A 1.949±0.00 N/A 9.266±0.00 8.447±0.00 N/A 5.398±0.00 3.507±0.00 N/A 3.331±0.00 24.500±16.86 N/A 13.279±0.00
ENST00000530291 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 9.790±0.00 N/A N/A N/A

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0002026 IEA regulation of the force of heart contraction
GO:0002029 ISS desensitization of G-protein coupled receptor protein signaling pathway
GO:0003108 IMP negative regulation of the force of heart contraction by chemical signal
GO:0004672 ISS:IEA protein kinase activity
GO:0004674 IEA protein serine/threonine kinase activity
GO:0004703 ISS G-protein coupled receptor kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005737 IDA cytoplasm
GO:0005829 TAS cytosol
GO:0005886 TAS plasma membrane
GO:0006468 IEA protein phosphorylation
GO:0007165 TAS signal transduction
GO:0007173 TAS epidermal growth factor receptor signaling pathway
GO:0007186 IEA G-protein coupled receptor signaling pathway
GO:0007202 TAS activation of phospholipase C activity
GO:0007213 ISS G-protein coupled acetylcholine receptor signaling pathway
GO:0007217 IDA tachykinin receptor signaling pathway
GO:0007507 IEA heart development
GO:0008277 IEA regulation of G-protein coupled receptor protein signaling pathway
GO:0008543 TAS fibroblast growth factor receptor signaling pathway
GO:0016020 ISS membrane
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0018105 ISS peptidyl-serine phosphorylation
GO:0018107 IEA peptidyl-threonine phosphorylation
GO:0031623 IDA receptor internalization
GO:0031694 ISS alpha-2A adrenergic receptor binding
GO:0031755 IDA Edg-2 lysophosphatidic acid receptor binding
GO:0033605 ISS positive regulation of catecholamine secretion
GO:0038032 IEA termination of G-protein coupled receptor signaling pathway
GO:0045087 TAS innate immune response
GO:0045988 IMP negative regulation of striated muscle contraction
GO:0047696 IEA beta-adrenergic receptor kinase activity
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0060048 IMP cardiac muscle contraction

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSMUSG00000024858 Adrbk1 adrenergic receptor kinase, beta 1 protein_coding Mus_musculus

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