C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: adrenergic receptor kinase, beta 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000024858 Adrbk1 10090 - 19:4286001-4306222 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000025791 Adrbk1-002 4286001-4305955 protein_coding
  ENSMUST00000088737 Adrbk1-001 4286002-4306222 protein_coding
  ENSMUST00000113837 Adrbk1-004 4286001-4306030 nonsense_mediated_decay
  ENSMUST00000164427 Adrbk1-008 4288142-4289403 retained_intron
  ENSMUST00000165954 Adrbk1-007 4288426-4290483 protein_coding
  ENSMUST00000167172 Adrbk1-006 4291347-4306027 retained_intron
  ENSMUST00000167511 Adrbk1-003 4292567-4305208 protein_coding
  ENSMUST00000168594 Adrbk1-009 4288396-4289394 protein_coding
  ENSMUST00000169991 Adrbk1-005 4290462-4291811 retained_intron
  ENSMUST00000171123 Adrbk1-010 4286021-4306214 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000025791ENSMUST00000088737ENSMUST00000113837ENSMUST00000165954ENSMUST00000167511ENSMUST00000171123
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000025791 18.519±3.19 18.058±6.52 6.615±0.14 N/A 52.455±19.39 26.420±9.54 6.211±2.41 12.865±4.34 9.499±3.04 24.890±7.25 N/A 25.622±6.96 15.446±9.11 1.932±0.63
ENSMUST00000088737 9.297±4.46 9.573±2.46 16.204±3.78 12.693±0.34 23.207±5.36 17.468±5.47 12.192±2.53 8.359±2.36 7.233±4.31 12.791±4.19 18.183±1.90 8.273±4.06 13.373±5.02 2.118±0.80
ENSMUST00000113837 N/A 2.781±0.00 N/A N/A N/A N/A N/A N/A 1.730±0.00 5.817±0.82 N/A N/A 5.077±0.00 N/A
ENSMUST00000165954 N/A N/A N/A 159.107±0.00 N/A N/A N/A N/A N/A N/A N/A 53.769±0.00 96.951±20.66 3.786±0.00
ENSMUST00000167511 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 60.528±0.00 108.524±0.00 11.294±0.00
ENSMUST00000171123 N/A N/A N/A N/A 14.751±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0002026 IGI regulation of the force of heart contraction
GO:0002029 IMP desensitization of G-protein coupled receptor protein signaling pathway
GO:0003108 IEA negative regulation of the force of heart contraction by chemical signal
GO:0004672 IDA protein kinase activity
GO:0004674 IDA protein serine/threonine kinase activity
GO:0004703 IDA G-protein coupled receptor kinase activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005737 IEA cytoplasm
GO:0006468 IDA protein phosphorylation
GO:0007186 IDA G-protein coupled receptor signaling pathway
GO:0007217 IEA tachykinin receptor signaling pathway
GO:0007507 IMP heart development
GO:0016020 IDA membrane
GO:0018105 IDA peptidyl-serine phosphorylation
GO:0018107 IDA peptidyl-threonine phosphorylation
GO:0031623 IEA receptor internalization
GO:0031755 IEA Edg-2 lysophosphatidic acid receptor binding
GO:0038032 IEA termination of G-protein coupled receptor signaling pathway
GO:0045988 IEA negative regulation of striated muscle contraction
GO:0047696 IEA beta-adrenergic receptor kinase activity
GO:0060048 IEA cardiac muscle contraction

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSG00000173020 ADRBK1 adrenergic, beta, receptor kinase 1 protein_coding Homo_sapiens

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