C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: adrenergic, beta, receptor kinase 1
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000308595 ADRBK1-001 ENSG00000173020 9606 + 11:67266410-67286556 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000308595
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000308595 21.250±0.00 66.660±0.00 1.260±0.00 21.695±12.44 12.053±6.43 13.755±10.01 9.844±8.88 11.481±10.02 7.183±5.16 17.439±13.13 12.104±8.91 26.583±12.72 25.976±4.02 14.755±4.28

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology

GO IDEvidence TypeGO Description
GO:0002026 IEA regulation of the force of heart contraction
GO:0002029 ISS desensitization of G-protein coupled receptor protein signaling pathway
GO:0003108 IMP negative regulation of the force of heart contraction by chemical signal
GO:0004672 ISS:IEA protein kinase activity
GO:0004674 IEA protein serine/threonine kinase activity
GO:0004703 ISS G-protein coupled receptor kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005737 IDA cytoplasm
GO:0005829 TAS cytosol
GO:0005886 TAS plasma membrane
GO:0006468 IEA protein phosphorylation
GO:0007165 TAS signal transduction
GO:0007173 TAS epidermal growth factor receptor signaling pathway
GO:0007186 IEA G-protein coupled receptor signaling pathway
GO:0007202 TAS activation of phospholipase C activity
GO:0007213 ISS G-protein coupled acetylcholine receptor signaling pathway
GO:0007217 IDA tachykinin receptor signaling pathway
GO:0007507 IEA heart development
GO:0008277 IEA regulation of G-protein coupled receptor protein signaling pathway
GO:0008543 TAS fibroblast growth factor receptor signaling pathway
GO:0016020 ISS membrane
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0018105 ISS peptidyl-serine phosphorylation
GO:0018107 IEA peptidyl-threonine phosphorylation
GO:0031623 IDA receptor internalization
GO:0031694 ISS alpha-2A adrenergic receptor binding
GO:0031755 IDA Edg-2 lysophosphatidic acid receptor binding
GO:0033605 ISS positive regulation of catecholamine secretion
GO:0038032 IEA termination of G-protein coupled receptor signaling pathway
GO:0045087 TAS innate immune response
GO:0045988 IMP negative regulation of striated muscle contraction
GO:0047696 IEA beta-adrenergic receptor kinase activity
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0060048 IMP cardiac muscle contraction

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000088737 Adrbk1-001 protein_coding Mus_musculus 0 3066
ENSMUST00000025791 Adrbk1-002 protein_coding Mus_musculus 0 2712
ENSMUST00000171123 Adrbk1-010 protein_coding Mus_musculus 0 1589
ENSMUST00000065167 Adrbk2-201 protein_coding Mus_musculus 0 1153
ENSMUST00000113837 Adrbk1-004 nonsense_mediated_decay Mus_musculus 0 1083
ENSMUST00000167172 Adrbk1-006 retained_intron Mus_musculus 0 774
ENSMUST00000165954 Adrbk1-007 protein_coding Mus_musculus 0 697
ENSMUST00000169991 Adrbk1-005 retained_intron Mus_musculus 0 531

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