C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: signal transducer and activator of transcription 5B
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000173757 STAT5B 9606 - 17:42199168-42276707 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000293328 STAT5B-001 42199168-42276406 protein_coding
  ENST00000415845 STAT5B-003 42223463-42276707 protein_coding
  ENST00000468312 STAT5B-002 42217690-42276406 retained_intron
  ENST00000468496 STAT5B-006 42207582-42217282 retained_intron
  ENST00000481253 STAT5B-005 42207559-42210592 retained_intron
  ENST00000481517 STAT5B-004 42210417-42217871 retained_intron
  ENST00000498674 STAT5B-007 42202103-42202953 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000293328ENST00000468312
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000293328 17.059±0.00 10.620±0.00 2.552±0.00 4.278±3.03 21.469±0.00 13.485±0.00 3.960±2.49 4.716±2.45 4.556±1.27 13.174±10.00 16.804±14.95 8.818±8.01 11.393±2.56 10.570±8.16
ENST00000468312 N/A N/A N/A N/A N/A 1.006±0.00 N/A N/A N/A N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0000KW CIL_0000KW_0002 CGP 17:42188799-42276707
CIL_0006I7 CIL_0006I7_0001 CGP 17:42199168-42311943

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000255 ISS allantoin metabolic process
GO:0000979 IEA RNA polymerase II core promoter sequence-specific DNA binding
GO:0001553 IEA luteinization
GO:0001666 IEA response to hypoxia
GO:0001779 IEA natural killer cell differentiation
GO:0001889 IEA liver development
GO:0003677 IEA DNA binding
GO:0003682 ISS chromatin binding
GO:0003690 IEA double-stranded DNA binding
GO:0003700 IEA sequence-specific DNA binding transcription factor activity
GO:0004871 IEA signal transducer activity
GO:0005509 IEA calcium ion binding
GO:0005515 IPI protein binding
GO:0005634 ISS:IEA nucleus
GO:0005654 TAS nucleoplasm
GO:0005737 ISS cytoplasm
GO:0005829 TAS cytosol
GO:0006101 ISS citrate metabolic process
GO:0006103 ISS 2-oxoglutarate metabolic process
GO:0006105 ISS succinate metabolic process
GO:0006107 ISS oxaloacetate metabolic process
GO:0006355 IEA regulation of transcription, DNA-templated
GO:0006357 TAS regulation of transcription from RNA polymerase II promoter
GO:0006366 IEA transcription from RNA polymerase II promoter
GO:0006549 ISS isoleucine metabolic process
GO:0006573 ISS valine metabolic process
GO:0006600 ISS creatine metabolic process
GO:0006631 ISS fatty acid metabolic process
GO:0006953 IEA acute-phase response
GO:0007165 IEA signal transduction
GO:0007259 TAS JAK-STAT cascade
GO:0007548 IEA sex differentiation
GO:0007565 IEA female pregnancy
GO:0007595 IEA lactation
GO:0008284 IEA positive regulation of cell proliferation
GO:0019218 IEA regulation of steroid metabolic process
GO:0019221 IEA cytokine-mediated signaling pathway
GO:0019530 ISS taurine metabolic process
GO:0019903 IEA protein phosphatase binding
GO:0019915 IEA lipid storage
GO:0030155 IEA regulation of cell adhesion
GO:0030856 IEA regulation of epithelial cell differentiation
GO:0032355 IDA response to estradiol
GO:0032496 IEA response to lipopolysaccharide
GO:0032819 IEA positive regulation of natural killer cell proliferation
GO:0032825 IEA positive regulation of natural killer cell differentiation
GO:0032870 IDA cellular response to hormone stimulus
GO:0033077 IEA T cell differentiation in thymus
GO:0035259 IPI glucocorticoid receptor binding
GO:0038161 ISS prolactin signaling pathway
GO:0040014 ISS regulation of multicellular organism growth
GO:0040018 IEA positive regulation of multicellular organism growth
GO:0042104 IEA positive regulation of activated T cell proliferation
GO:0042448 IEA progesterone metabolic process
GO:0043029 IEA T cell homeostasis
GO:0043066 IEA negative regulation of apoptotic process
GO:0043434 IEA response to peptide hormone
GO:0043565 IEA sequence-specific DNA binding
GO:0045086 IEA positive regulation of interleukin-2 biosynthetic process
GO:0045471 IEA response to ethanol
GO:0045579 IEA positive regulation of B cell differentiation
GO:0045588 IEA positive regulation of gamma-delta T cell differentiation
GO:0045621 IEA positive regulation of lymphocyte differentiation
GO:0045647 IEA negative regulation of erythrocyte differentiation
GO:0045931 IEA positive regulation of mitotic cell cycle
GO:0045944 ISS positive regulation of transcription from RNA polymerase II promoter
GO:0045954 IEA positive regulation of natural killer cell mediated cytotoxicity
GO:0046449 ISS creatinine metabolic process
GO:0046543 IEA development of secondary female sexual characteristics
GO:0046544 IEA development of secondary male sexual characteristics
GO:0046983 ISS protein dimerization activity
GO:0048541 IEA Peyer's patch development
GO:0048661 IEA positive regulation of smooth muscle cell proliferation
GO:0050729 IEA positive regulation of inflammatory response
GO:0051272 IEA positive regulation of cellular component movement
GO:0060397 IDA JAK-STAT cascade involved in growth hormone signaling pathway
GO:0070669 IEA response to interleukin-2
GO:0070670 IEA response to interleukin-4
GO:0070672 IEA response to interleukin-15
GO:0071363 ISS cellular response to growth factor stimulus
GO:0071364 ISS cellular response to epidermal growth factor stimulus

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000019392 stat5.1 signal transducer and activator of transcription 5.1 protein_coding Danio_rerio
ENSDARG00000055588 stat5.2 signal transducer and activator of transcription 5.2 protein_coding Danio_rerio
ENSMUSG00000020919 Stat5b signal transducer and activator of transcription 5B protein_coding Mus_musculus

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