C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: ATR serine/threonine kinase
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000175054 ATR 9606 - 3:142449235-142578826 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000350721 ATR-001 142449237-142578826 protein_coding
  ENST00000504521 ATR-013 142449235-142457710 nonsense_mediated_decay
  ENST00000507148 ATR-003 142560339-142578724 nonsense_mediated_decay
  ENST00000507620 ATR-007 142496397-142500102 retained_intron
  ENST00000511016 ATR-010 142452753-142457803 retained_intron
  ENST00000513291 ATR-002 142449238-142469427 protein_coding
  ENST00000514393 ATR-008 142496390-142499192 processed_transcript
  ENST00000515149 ATR-005 142556383-142562444 protein_coding
  ENST00000515810 ATR-014 142449237-142453166 nonsense_mediated_decay
  ENST00000515863 ATR-011 142556070-142559001 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000350721ENST00000504521ENST00000513291
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000350721 0.936±0.00 2.225±0.00 1.380±0.00 1.837±0.54 0.702±0.00 1.896±1.46 0.609±0.04 0.753±0.00 1.954±1.50 0.739±0.00 0.324±0.00 1.664±0.99 0.522±0.39 1.021±0.12
ENST00000504521 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 1.177±0.00 N/A N/A N/A
ENST00000513291 N/A 0.960±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000077 IDA DNA damage checkpoint
GO:0001741 IEA XY body
GO:0003677 IEA DNA binding
GO:0004672 IDA protein kinase activity
GO:0004674 IDA:IEA protein serine/threonine kinase activity
GO:0005488 IEA binding
GO:0005515 IPI:IEA protein binding
GO:0005524 IEA ATP binding
GO:0005654 TAS nucleoplasm
GO:0005694 ISS chromosome
GO:0006260 TAS DNA replication
GO:0006281 TAS DNA repair
GO:0006468 IEA protein phosphorylation
GO:0006974 TAS cellular response to DNA damage stimulus
GO:0007049 TAS cell cycle
GO:0007275 TAS multicellular organismal development
GO:0008152 IEA metabolic process
GO:0008156 IMP negative regulation of DNA replication
GO:0016605 IDA PML body
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0016773 IEA phosphotransferase activity, alcohol group as acceptor
GO:0018105 IDA peptidyl-serine phosphorylation
GO:0032405 IDA MutLalpha complex binding
GO:0032407 IDA MutSalpha complex binding
GO:0034644 IMP cellular response to UV
GO:0042493 IEA response to drug
GO:0043393 IEA regulation of protein binding
GO:0043517 IMP positive regulation of DNA damage response, signal transduction by p53 class mediator
GO:0046777 IDA protein autophosphorylation
GO:0071480 IDA cellular response to gamma radiation
GO:0090399 IMP replicative senescence

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000079625 atr ataxia telangiectasia and Rad3 related protein_coding Danio_rerio
ENSMUSG00000032409 Atr ataxia telangiectasia and Rad3 related protein_coding Mus_musculus

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