C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: TNF receptor-associated factor 6, E3 ubiquitin protein ligase
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000175104 TRAF6 9606 - 11:36487027-36510272 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000348124 TRAF6-002 36489173-36510256 protein_coding
  ENST00000526995 TRAF6-001 36487027-36510272 protein_coding
  ENST00000529150 TRAF6-003 36490377-36496510 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000348124ENST00000526995
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000348124 1.127±0.00 1.087±0.00 N/A 0.716±0.13 0.975±0.00 0.770±0.00 0.584±0.00 1.447±0.71 0.402±0.00 1.225±0.00 N/A 1.208±0.08 1.148±0.26 2.208±0.08
ENST00000526995 0.434±0.00 1.493±0.00 0.805±0.00 0.278±0.00 1.779±0.59 0.575±0.00 1.109±0.80 2.346±0.00 0.598±0.00 1.483±1.03 1.124±0.80 1.249±0.33 0.711±0.10 1.067±0.33

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IMP negative regulation of transcription from RNA polymerase II promoter
GO:0000187 TAS activation of MAPK activity
GO:0000209 IDA protein polyubiquitination
GO:0001503 IEA ossification
GO:0001843 IEA neural tube closure
GO:0002224 TAS toll-like receptor signaling pathway
GO:0002726 IMP positive regulation of T cell cytokine production
GO:0002755 TAS MyD88-dependent toll-like receptor signaling pathway
GO:0002756 TAS MyD88-independent toll-like receptor signaling pathway
GO:0004842 IDA ubiquitin-protein transferase activity
GO:0004871 IEA signal transducer activity
GO:0005164 IPI tumor necrosis factor receptor binding
GO:0005515 IPI:IEA protein binding
GO:0005634 IDA nucleus
GO:0005730 IDA nucleolus
GO:0005737 IDA cytoplasm
GO:0005739 IDA mitochondrion
GO:0005811 ISS lipid particle
GO:0005829 TAS cytosol
GO:0005886 IDA plasma membrane
GO:0006461 IEA protein complex assembly
GO:0006955 IEA immune response
GO:0007165 IEA signal transduction
GO:0007249 TAS I-kappaB kinase/NF-kappaB signaling
GO:0007250 IMP activation of NF-kappaB-inducing kinase activity
GO:0007254 TAS JNK cascade
GO:0008270 IEA zinc ion binding
GO:0009887 IEA organ morphogenesis
GO:0009898 ISS cytoplasmic side of plasma membrane
GO:0010008 TAS endosome membrane
GO:0016567 IEA protein ubiquitination
GO:0016874 IEA ligase activity
GO:0019221 IEA cytokine-mediated signaling pathway
GO:0019886 IEA antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0019901 IPI protein kinase binding
GO:0030316 IEA osteoclast differentiation
GO:0031293 TAS membrane protein intracellular domain proteolysis
GO:0031398 NAS positive regulation of protein ubiquitination
GO:0031435 IPI mitogen-activated protein kinase kinase kinase binding
GO:0031624 IDA ubiquitin conjugating enzyme binding
GO:0031625 IPI ubiquitin protein ligase binding
GO:0031666 IEA positive regulation of lipopolysaccharide-mediated signaling pathway
GO:0031996 IPI thioesterase binding
GO:0032147 IDA activation of protein kinase activity
GO:0032743 IMP positive regulation of interleukin-2 production
GO:0034134 TAS toll-like receptor 2 signaling pathway
GO:0034138 TAS toll-like receptor 3 signaling pathway
GO:0034142 TAS toll-like receptor 4 signaling pathway
GO:0034146 TAS toll-like receptor 5 signaling pathway
GO:0034162 TAS toll-like receptor 9 signaling pathway
GO:0034166 TAS toll-like receptor 10 signaling pathway
GO:0035631 ISS CD40 receptor complex
GO:0035666 TAS TRIF-dependent toll-like receptor signaling pathway
GO:0035872 TAS nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO:0038095 TAS Fc-epsilon receptor signaling pathway
GO:0038123 TAS toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124 TAS toll-like receptor TLR6:TLR2 signaling pathway
GO:0042088 IEA T-helper 1 type immune response
GO:0042102 IEA positive regulation of T cell proliferation
GO:0042475 IEA odontogenesis of dentin-containing tooth
GO:0042826 IPI histone deacetylase binding
GO:0042981 IEA regulation of apoptotic process
GO:0043011 IEA myeloid dendritic cell differentiation
GO:0043065 TAS positive regulation of apoptotic process
GO:0043066 TAS negative regulation of apoptotic process
GO:0043123 IDA positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043234 IDA protein complex
GO:0043422 IPI protein kinase B binding
GO:0043507 IDA positive regulation of JUN kinase activity
GO:0045084 IEA positive regulation of interleukin-12 biosynthetic process
GO:0045087 TAS innate immune response
GO:0045410 IEA positive regulation of interleukin-6 biosynthetic process
GO:0045453 IEA bone resorption
GO:0045672 IDA positive regulation of osteoclast differentiation
GO:0045892 IMP negative regulation of transcription, DNA-templated
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0046849 IEA bone remodeling
GO:0046872 IEA metal ion binding
GO:0047485 IPI protein N-terminus binding
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0048468 IEA cell development
GO:0048471 IDA perinuclear region of cytoplasm
GO:0048661 IEA positive regulation of smooth muscle cell proliferation
GO:0050852 IMP T cell receptor signaling pathway
GO:0050870 IC positive regulation of T cell activation
GO:0051023 IEA regulation of immunoglobulin secretion
GO:0051091 IMP positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051092 IDA positive regulation of NF-kappaB transcription factor activity
GO:0051403 TAS stress-activated MAPK cascade
GO:0051865 TAS protein autoubiquitination
GO:0070423 TAS nucleotide-binding oligomerization domain containing signaling pathway
GO:0070498 IEA interleukin-1-mediated signaling pathway
GO:0070534 IGI protein K63-linked ubiquitination
GO:0070555 IDA response to interleukin-1
GO:0071222 IDA cellular response to lipopolysaccharide
GO:0097190 TAS apoptotic signaling pathway
GO:2000679 IDA positive regulation of transcription regulatory region DNA binding

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000028058 traf6 TNF receptor-associated factor 6 protein_coding Danio_rerio
ENSMUSG00000027164 Traf6 TNF receptor-associated factor 6 protein_coding Mus_musculus

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