C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: TNF receptor-associated factor 6
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000027164 Traf6 10090 + 2:101678429-101701669 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000004949 Traf6-001 101678440-101701669 protein_coding
  ENSMUST00000143341 Traf6-002 101678429-101686235 processed_transcript
  ENSMUST00000144063 Traf6-003 101684215-101690085 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000004949ENSMUST00000143341
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000004949 5.299±1.76 5.969±0.31 2.656±0.72 1.478±0.84 7.717±0.67 4.666±0.71 2.178±0.47 5.888±0.71 2.766±1.34 8.161±0.45 2.352±0.66 6.759±1.83 2.430±1.42 0.698±0.30
ENSMUST00000143341 N/A 2.355±0.61 N/A N/A 2.040±0.00 1.565±0.35 N/A N/A N/A N/A N/A 2.740±0.50 N/A 0.300±0.00

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IEA negative regulation of transcription from RNA polymerase II promoter
GO:0000209 IEA protein polyubiquitination
GO:0001503 IMP ossification
GO:0001843 IMP neural tube closure
GO:0002726 IEA positive regulation of T cell cytokine production
GO:0004842 IDA ubiquitin-protein transferase activity
GO:0004871 TAS signal transducer activity
GO:0005164 IEA tumor necrosis factor receptor binding
GO:0005515 IPI protein binding
GO:0005634 IEA nucleus
GO:0005730 IEA nucleolus
GO:0005737 IEA cytoplasm
GO:0005739 IEA mitochondrion
GO:0005811 IDA lipid particle
GO:0005829 IDA cytosol
GO:0005886 IEA plasma membrane
GO:0006461 IEA protein complex assembly
GO:0006955 IMP immune response
GO:0007165 IDA signal transduction
GO:0007249 IMP I-kappaB kinase/NF-kappaB signaling
GO:0007250 IEA activation of NF-kappaB-inducing kinase activity
GO:0007254 IEA JNK cascade
GO:0008270 IEA zinc ion binding
GO:0009887 IMP organ morphogenesis
GO:0009898 IDA cytoplasmic side of plasma membrane
GO:0016567 IGI protein ubiquitination
GO:0016874 IEA ligase activity
GO:0019221 IEA cytokine-mediated signaling pathway
GO:0019886 IMP antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0019901 IEA protein kinase binding
GO:0030316 IMP osteoclast differentiation
GO:0031435 IEA mitogen-activated protein kinase kinase kinase binding
GO:0031624 ISO ubiquitin conjugating enzyme binding
GO:0031625 IEA ubiquitin protein ligase binding
GO:0031666 IMP positive regulation of lipopolysaccharide-mediated signaling pathway
GO:0031996 IEA thioesterase binding
GO:0032147 IEA activation of protein kinase activity
GO:0032743 IEA positive regulation of interleukin-2 production
GO:0035631 IDA CD40 receptor complex
GO:0042088 IMP T-helper 1 type immune response
GO:0042102 IMP positive regulation of T cell proliferation
GO:0042475 IMP odontogenesis of dentin-containing tooth
GO:0042826 IEA histone deacetylase binding
GO:0042981 IEA regulation of apoptotic process
GO:0043011 IMP myeloid dendritic cell differentiation
GO:0043123 IMP positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043234 ISO protein complex
GO:0043422 IEA protein kinase B binding
GO:0043507 IEA positive regulation of JUN kinase activity
GO:0045084 IMP positive regulation of interleukin-12 biosynthetic process
GO:0045410 IMP positive regulation of interleukin-6 biosynthetic process
GO:0045453 IMP bone resorption
GO:0045672 IEA positive regulation of osteoclast differentiation
GO:0045892 IEA negative regulation of transcription, DNA-templated
GO:0045944 IEA positive regulation of transcription from RNA polymerase II promoter
GO:0046849 IMP bone remodeling
GO:0047485 IEA protein N-terminus binding
GO:0048468 IMP cell development
GO:0048471 IEA perinuclear region of cytoplasm
GO:0048661 IEA positive regulation of smooth muscle cell proliferation
GO:0050852 IEA T cell receptor signaling pathway
GO:0051023 IDA regulation of immunoglobulin secretion
GO:0051091 IEA positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051092 IMP positive regulation of NF-kappaB transcription factor activity
GO:0051865 TAS protein autoubiquitination
GO:0070498 IMP interleukin-1-mediated signaling pathway
GO:0070534 IDA protein K63-linked ubiquitination
GO:0070555 IEA response to interleukin-1
GO:0071222 ISO cellular response to lipopolysaccharide
GO:2000679 IEA positive regulation of transcription regulatory region DNA binding

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000028058 traf6 TNF receptor-associated factor 6 protein_coding Danio_rerio
ENSG00000175104 TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase protein_coding Homo_sapiens

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