C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: proprotein convertase subtilisin/kexin type 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000175426 PCSK1 9606 - 5:96390415-96434143 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000311106 PCSK1-001 96390415-96433280 protein_coding
  ENST00000508626 PCSK1-002 96392927-96432160 protein_coding
  ENST00000509190 PCSK1-005 96423383-96434143 protein_coding
  ENST00000513085 PCSK1-004 96392925-96412985 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000311106ENST00000508626ENST00000509190ENST00000513085
Transcript ID Adipose Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000311106 0.473±0.00 0.123±0.00 2.260±0.76 5.361±0.00 0.222±0.08 0.062±0.00 0.026±0.00 N/A N/A 0.095±0.00 0.100±0.11 0.019±0.01 0.056±0.03
ENST00000508626 0.599±0.00 N/A 5.556±0.00 7.215±0.00 0.135±0.00 0.067±0.00 N/A 0.011±0.00 0.283±0.00 N/A N/A 0.008±0.00 N/A
ENST00000509190 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.180±0.00 N/A
ENST00000513085 N/A N/A N/A N/A 0.305±0.00 N/A N/A N/A N/A N/A 0.051±0.00 N/A 0.191±0.00

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004175 IEA endopeptidase activity
GO:0004252 ISS:IEA serine-type endopeptidase activity
GO:0005615 IDA extracellular space
GO:0005794 IBA Golgi apparatus
GO:0006508 IEA proteolysis
GO:0007267 TAS cell-cell signaling
GO:0008152 TAS metabolic process
GO:0016485 IEA protein processing
GO:0016486 TAS peptide hormone processing
GO:0034774 TAS secretory granule lumen
GO:0043043 ISS peptide biosynthetic process
GO:0044267 TAS cellular protein metabolic process
GO:0050796 TAS regulation of insulin secretion

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000002600 pcsk1 proprotein convertase subtilisin/kexin type 1 protein_coding Danio_rerio
ENSMUSG00000021587 Pcsk1 proprotein convertase subtilisin/kexin type 1 protein_coding Mus_musculus

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