C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: proprotein convertase subtilisin/kexin type 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000021587 Pcsk1 10090 + 13:75089826-75132498 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000022075 Pcsk1-001 75089826-75132498 protein_coding
  ENSMUST00000135349 Pcsk1-002 75089916-75106603 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000022075ENSMUST00000135349
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000022075 0.075±0.05 3.912±0.33 0.042±0.00 4.024±3.70 0.059±0.04 3.497±0.40 0.031±0.01 0.015±0.00 0.003±0.00 0.237±0.14 0.050±0.03 0.090±0.03 0.014±0.01 0.094±0.04
ENSMUST00000135349 N/A N/A N/A N/A 0.158±0.05 N/A 0.038±0.01 0.102±0.09 N/A N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0000JE CIL_0000JE_0002 CGP 13:74694286-75132498
CIL_00002O CIL_00002O_0002 CGP 13:75089826-75772356

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004175 IDA endopeptidase activity
GO:0004252 IDA serine-type endopeptidase activity
GO:0005615 IDA extracellular space
GO:0005788 TAS endoplasmic reticulum lumen
GO:0005794 IBA Golgi apparatus
GO:0006508 IEA proteolysis
GO:0016485 IDA protein processing
GO:0016486 IDA peptide hormone processing
GO:0034774 TAS secretory granule lumen
GO:0043043 IDA peptide biosynthetic process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000002600 pcsk1 proprotein convertase subtilisin/kexin type 1 protein_coding Danio_rerio
ENSG00000175426 PCSK1 proprotein convertase subtilisin/kexin type 1 protein_coding Homo_sapiens

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