C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: thymidylate synthetase
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000176890 TYMS 9606 + 18:657604-673578 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000323224 TYMS-002 657743-673484 protein_coding
  ENST00000323250 TYMS-003 657743-672997 protein_coding
  ENST00000323274 TYMS-001 657604-673578 protein_coding
  ENST00000579128 TYMS-006 657665-669464 retained_intron
  ENST00000581920 TYMS-005 667721-673363 processed_transcript
  ENST00000584122 TYMS-004 658264-659689 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; ColonHeartOvaryPlacentaTestisENST00000323224ENST00000323274ENST00000579128
Transcript ID Colon Heart Ovary Placenta Testis
ENST00000323224 N/A 3.088±0.00 N/A N/A N/A
ENST00000323274 3.542±0.00 N/A 15.765±10.78 19.100±3.71 18.454±0.54
ENST00000579128 N/A N/A N/A N/A 19.930±0.00

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000082 TAS G1/S transition of mitotic cell cycle
GO:0000083 TAS regulation of transcription involved in G1/S transition of mitotic cell cycle
GO:0000166 IEA nucleotide binding
GO:0000278 TAS mitotic cell cycle
GO:0003729 IEA mRNA binding
GO:0004799 TAS:IEA thymidylate synthase activity
GO:0005542 IEA folic acid binding
GO:0005634 IDA nucleus
GO:0005654 TAS nucleoplasm
GO:0005730 IEA nucleolus
GO:0005737 IDA cytoplasm
GO:0005739 IDA mitochondrion
GO:0005743 IDA mitochondrial inner membrane
GO:0005759 IDA mitochondrial matrix
GO:0005829 TAS cytosol
GO:0006139 TAS nucleobase-containing compound metabolic process
GO:0006206 TAS pyrimidine nucleobase metabolic process
GO:0006231 IEA dTMP biosynthetic process
GO:0006235 IEA dTTP biosynthetic process
GO:0007568 IEA aging
GO:0007623 IEA circadian rhythm
GO:0008144 IEA drug binding
GO:0009157 TAS deoxyribonucleoside monophosphate biosynthetic process
GO:0009636 IEA response to toxic substance
GO:0014070 IEA response to organic cyclic compound
GO:0019088 IEA immortalization of host cell by virus
GO:0019860 IEA uracil metabolic process
GO:0031100 IEA organ regeneration
GO:0032259 IEA methylation
GO:0032570 IEA response to progesterone
GO:0033189 IEA response to vitamin A
GO:0034097 IEA response to cytokine
GO:0042493 IEA response to drug
GO:0042803 IEA protein homodimerization activity
GO:0044281 TAS small molecule metabolic process
GO:0045471 IEA response to ethanol
GO:0046078 IEA dUMP metabolic process
GO:0046134 TAS pyrimidine nucleoside biosynthetic process
GO:0046653 IEA tetrahydrofolate metabolic process
GO:0046683 IEP response to organophosphorus
GO:0048037 IEA cofactor binding
GO:0048589 IEA developmental growth
GO:0051216 IEA cartilage development
GO:0051384 IEA response to glucocorticoid
GO:0051593 IEA response to folic acid
GO:0055086 TAS nucleobase-containing small molecule metabolic process
GO:0060574 IEA intestinal epithelial cell maturation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000042894 tyms thymidylate synthase protein_coding Danio_rerio
ENSMUSG00000025747 Tyms thymidylate synthase protein_coding Mus_musculus

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