C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: thymidylate synthase
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000025747 Tyms 10090 - 5:30058202-30073617 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000026846 Tyms-001 30058827-30073617 protein_coding
  ENSMUST00000134298 Tyms-006 30063846-30073586 retained_intron
  ENSMUST00000138520 Tyms-005 30067891-30073522 processed_transcript
  ENSMUST00000141630 Tyms-002 30058202-30073581 nonsense_mediated_decay
  ENSMUST00000146520 Tyms-004 30061064-30070035 processed_transcript
  ENSMUST00000154751 Tyms-003 30069917-30073614 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000026846ENSMUST00000134298ENSMUST00000141630ENSMUST00000146520ENSMUST00000154751
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000026846 1.985±0.90 1.828±0.54 1.164±0.20 3.075±2.70 1.538±0.51 3.493±0.48 0.621±0.12 2.138±0.46 4.961±3.56 1.893±0.15 0.453±0.12 3.202±1.35 2.185±1.65 1.770±0.74
ENSMUST00000134298 4.748±1.85 9.356±3.56 2.829±0.00 3.120±0.00 7.697±0.26 24.835±4.66 0.703±0.00 5.873±0.41 19.190±19.90 4.087±1.32 N/A 19.422±7.17 14.192±7.50 N/A
ENSMUST00000141630 N/A N/A 0.379±0.00 0.464±0.31 0.528±0.15 N/A N/A N/A N/A 0.517±0.00 0.050±0.01 0.828±0.42 0.077±0.00 0.055±0.00
ENSMUST00000146520 5.969±2.77 2.444±0.00 4.267±0.00 4.260±0.00 4.299±0.63 8.596±0.56 0.949±0.00 7.156±1.26 31.035±29.12 N/A 0.351±0.00 10.475±2.94 15.548±16.65 N/A
ENSMUST00000154751 N/A N/A N/A 0.853±0.62 N/A N/A 0.226±0.02 N/A N/A 1.029±0.00 N/A 2.064±0.00 N/A N/A

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000166 IEA nucleotide binding
GO:0003729 IEA mRNA binding
GO:0004799 IEA thymidylate synthase activity
GO:0005542 IEA folic acid binding
GO:0005634 ISS nucleus
GO:0005730 IEA nucleolus
GO:0005737 ISS cytoplasm
GO:0005739 ISS mitochondrion
GO:0005743 ISS mitochondrial inner membrane
GO:0005759 ISS mitochondrial matrix
GO:0006206 IEA pyrimidine nucleobase metabolic process
GO:0006231 IEA dTMP biosynthetic process
GO:0006235 IEA dTTP biosynthetic process
GO:0007568 IEA aging
GO:0007623 IEA circadian rhythm
GO:0008144 IEA drug binding
GO:0009636 IEA response to toxic substance
GO:0014070 IEA response to organic cyclic compound
GO:0019088 IEA immortalization of host cell by virus
GO:0019860 IEA uracil metabolic process
GO:0031100 IEA organ regeneration
GO:0032259 IEA methylation
GO:0032570 IEA response to progesterone
GO:0033189 IEA response to vitamin A
GO:0034097 IEA response to cytokine
GO:0042493 IEA response to drug
GO:0042803 IEA protein homodimerization activity
GO:0045471 IEA response to ethanol
GO:0046078 IEA dUMP metabolic process
GO:0046653 IEA tetrahydrofolate metabolic process
GO:0046683 IEA response to organophosphorus
GO:0048037 IEA cofactor binding
GO:0048589 IEA developmental growth
GO:0051216 IEA cartilage development
GO:0051384 IEA response to glucocorticoid
GO:0051593 IEA response to folic acid
GO:0060574 IEA intestinal epithelial cell maturation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000042894 tyms thymidylate synthase protein_coding Danio_rerio
ENSG00000176890 TYMS thymidylate synthetase protein_coding Homo_sapiens

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