C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: growth factor receptor-bound protein 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000177885 GRB2 9606 - 17:75318076-75405709 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000316615 GRB2-201 75318076-75405709 protein_coding
  ENST00000316804 GRB2-001 75318076-75405653 protein_coding
  ENST00000392562 GRB2-002 75318076-75405486 protein_coding
  ENST00000392563 GRB2-004 75318076-75393656 protein_coding
  ENST00000392564 GRB2-003 75318076-75393864 protein_coding
  ENST00000462266 GRB2-005 75320345-75326338 processed_transcript
  ENST00000577711 GRB2-006 75393404-75405681 retained_intron
  ENST00000578961 GRB2-008 75320341-75393803 protein_coding
  ENST00000581959 GRB2-009 75318076-75321753 protein_coding
  ENST00000582582 GRB2-007 75321795-75394033 protein_coding
  ENST00000583912 GRB2-010 75387490-75393806 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000316615ENST00000316804ENST00000392563ENST00000392564ENST00000577711ENST00000578961
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000316615 N/A N/A N/A 2.104±0.00 N/A N/A 0.664±0.00 1.731±0.00 N/A 4.629±0.00 N/A 5.229±0.00 N/A N/A
ENST00000316804 31.682±0.00 50.409±0.00 0.929±0.00 16.480±12.08 17.265±15.58 11.246±7.31 8.369±6.66 16.250±13.84 12.244±8.71 40.297±0.00 7.316±6.24 15.737±7.06 37.773±11.12 12.213±6.34
ENST00000392563 N/A N/A 1.273±0.00 N/A N/A N/A N/A N/A N/A N/A N/A 11.929±0.00 13.942±0.00 4.651±0.00
ENST00000392564 N/A N/A N/A 7.871±6.28 4.654±0.00 5.361±3.36 N/A N/A 1.218±0.00 1.192±0.00 N/A 4.908±0.30 N/A 4.776±0.00
ENST00000577711 N/A N/A 2.165±0.00 N/A N/A N/A N/A N/A N/A N/A 3.540±0.00 N/A N/A N/A
ENST00000578961 N/A N/A 1.390±0.00 8.423±0.00 N/A 6.954±0.00 N/A N/A 4.500±0.00 7.070±0.00 1.320±0.00 51.052±0.00 96.396±0.00 28.772±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008PW CIL_0008PW_0001 VISTA 17:75051738-75652852
CIL_00021R CIL_00021R_0001 CGP 17:75272981-75405709
CIL_0007J0 CIL_0007J0_0001 CGP 17:75318076-75500090

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001784 IEA phosphotyrosine binding
GO:0005070 TAS SH3/SH2 adaptor activity
GO:0005154 IPI epidermal growth factor receptor binding
GO:0005168 IPI neurotrophin TRKA receptor binding
GO:0005515 IPI:IEA protein binding
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005768 IDA endosome
GO:0005794 IEA Golgi apparatus
GO:0005829 TAS cytosol
GO:0005886 TAS plasma membrane
GO:0005911 IEA cell-cell junction
GO:0007173 TAS epidermal growth factor receptor signaling pathway
GO:0007265 TAS Ras protein signal transduction
GO:0007267 TAS cell-cell signaling
GO:0007411 TAS axon guidance
GO:0007568 IEA aging
GO:0007596 TAS blood coagulation
GO:0008180 IDA COP9 signalosome
GO:0008286 IPI insulin receptor signaling pathway
GO:0008543 TAS fibroblast growth factor receptor signaling pathway
GO:0009967 IEA positive regulation of signal transduction
GO:0012506 IEA vesicle membrane
GO:0016020 IEA membrane
GO:0016032 IEA viral process
GO:0017124 IDA SH3 domain binding
GO:0019901 IPI protein kinase binding
GO:0019903 IEA protein phosphatase binding
GO:0019904 IEA protein domain specific binding
GO:0030154 IEA cell differentiation
GO:0030168 TAS platelet activation
GO:0030838 IEA positive regulation of actin filament polymerization
GO:0031295 TAS T cell costimulation
GO:0031623 IMP receptor internalization
GO:0038095 TAS Fc-epsilon receptor signaling pathway
GO:0038096 TAS Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0042059 TAS negative regulation of epidermal growth factor receptor signaling pathway
GO:0042770 IMP signal transduction in response to DNA damage
GO:0042802 IPI identical protein binding
GO:0043234 IEA protein complex
GO:0043408 IEA regulation of MAPK cascade
GO:0043560 IPI insulin receptor substrate binding
GO:0044822 IDA poly(A) RNA binding
GO:0045087 TAS innate immune response
GO:0046875 IPI ephrin receptor binding
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0048015 TAS phosphatidylinositol-mediated signaling
GO:0048646 IEA anatomical structure formation involved in morphogenesis
GO:0050900 TAS leukocyte migration
GO:0051219 IEA phosphoprotein binding
GO:0051291 IEA protein heterooligomerization
GO:0060670 IEA branching involved in labyrinthine layer morphogenesis
GO:0070062 IDA extracellular vesicular exosome
GO:0070436 IDA Grb2-EGFR complex
GO:0071479 IMP cellular response to ionizing radiation
GO:2000379 IMP positive regulation of reactive oxygen species metabolic process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000014709 grb2a growth factor receptor-bound protein 2a protein_coding Danio_rerio
ENSDARG00000038059 grb2b growth factor receptor-bound protein 2b protein_coding Danio_rerio
ENSMUSG00000059923 Grb2 growth factor receptor bound protein 2 protein_coding Mus_musculus

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