C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: growth factor receptor bound protein 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000059923 Grb2 10090 - 11:115644045-115708597 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000021090 Grb2-002 115644045-115708597 protein_coding
  ENSMUST00000106495 Grb2-004 115644650-115708576 protein_coding
  ENSMUST00000106497 Grb2-001 115644045-115699534 protein_coding
  ENSMUST00000106499 Grb2-003 115644045-115699307 protein_coding
  ENSMUST00000135065 Grb2-005 115649857-115699928 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000021090ENSMUST00000106495ENSMUST00000106497ENSMUST00000106499ENSMUST00000135065
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000021090 12.606±2.17 31.386±4.56 22.388±3.13 23.353±9.31 19.783±4.53 26.923±0.60 10.164±4.44 19.021±1.32 18.339±3.48 25.425±0.47 13.495±2.84 26.972±7.20 23.203±4.85 3.649±0.60
ENSMUST00000106495 N/A N/A N/A N/A 8.400±0.00 N/A N/A N/A N/A N/A N/A 6.049±0.00 N/A N/A
ENSMUST00000106497 6.214±1.04 N/A 4.263±0.22 15.322±0.64 3.982±0.00 N/A 6.698±3.67 N/A N/A N/A 6.761±1.71 16.832±12.68 18.008±19.17 0.577±0.09
ENSMUST00000106499 N/A 8.363±0.00 N/A 23.354±0.00 5.066±1.28 N/A N/A N/A N/A N/A N/A N/A 9.609±0.00 0.864±0.00
ENSMUST00000135065 N/A N/A N/A 215.669±0.00 N/A N/A N/A N/A N/A N/A N/A 134.341±0.00 310.897±218.08 13.364±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008PW CIL_0008PW_0002 VISTA 11:115369788-115971497
CIL_00021R CIL_00021R_0002 CGP 11:115614178-115708597
CIL_0007J0 CIL_0007J0_0002 CGP 11:115644045-115799366

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001784 IEA phosphotyrosine binding
GO:0005070 IDA SH3/SH2 adaptor activity
GO:0005154 IEA epidermal growth factor receptor binding
GO:0005168 IEA neurotrophin TRKA receptor binding
GO:0005515 IPI protein binding
GO:0005634 ISS nucleus
GO:0005737 IDA cytoplasm
GO:0005768 ISS endosome
GO:0005794 IEA Golgi apparatus
GO:0005829 TAS cytosol
GO:0005886 IDA plasma membrane
GO:0005911 IDA cell-cell junction
GO:0007265 TAS Ras protein signal transduction
GO:0007568 IEA aging
GO:0008180 IDA COP9 signalosome
GO:0008286 IEA insulin receptor signaling pathway
GO:0009967 IDA positive regulation of signal transduction
GO:0012506 IDA vesicle membrane
GO:0016020 IDA membrane
GO:0017124 ISS SH3 domain binding
GO:0019901 IEA protein kinase binding
GO:0019903 IPI protein phosphatase binding
GO:0019904 IPI protein domain specific binding
GO:0030154 IMP cell differentiation
GO:0030838 IGI positive regulation of actin filament polymerization
GO:0031623 IEA receptor internalization
GO:0042770 IEA signal transduction in response to DNA damage
GO:0042802 IEA identical protein binding
GO:0043234 IEA protein complex
GO:0043408 IGI regulation of MAPK cascade
GO:0043560 IEA insulin receptor substrate binding
GO:0044822 IEA poly(A) RNA binding
GO:0046875 IPI ephrin receptor binding
GO:0048646 IMP anatomical structure formation involved in morphogenesis
GO:0051219 IEA phosphoprotein binding
GO:0051291 IEA protein heterooligomerization
GO:0060670 IMP branching involved in labyrinthine layer morphogenesis
GO:0070062 IEA extracellular vesicular exosome
GO:0070436 IEA Grb2-EGFR complex
GO:0071479 IEA cellular response to ionizing radiation
GO:2000379 IEA positive regulation of reactive oxygen species metabolic process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000014709 grb2a growth factor receptor-bound protein 2a protein_coding Danio_rerio
ENSDARG00000038059 grb2b growth factor receptor-bound protein 2b protein_coding Danio_rerio
ENSG00000177885 GRB2 growth factor receptor-bound protein 2 protein_coding Homo_sapiens

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