C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: growth factor receptor-bound protein 2
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000316804 GRB2-001 ENSG00000177885 9606 - 17:75318076-75405653 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000316804
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000316804 31.682±0.00 50.409±0.00 0.929±0.00 16.480±12.08 17.265±15.58 11.246±7.31 8.369±6.66 16.250±13.84 12.244±8.71 40.297±0.00 7.316±6.24 15.737±7.06 37.773±11.12 12.213±6.34

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008PW CIL_0008PW_0001 VISTA 17:75051738-75652852
CIL_00021R CIL_00021R_0001 CGP 17:75272981-75405709
CIL_0007J0 CIL_0007J0_0001 CGP 17:75318076-75500090

Gene Ontology

GO IDEvidence TypeGO Description
GO:0005070 TAS SH3/SH2 adaptor activity
GO:0005154 IPI epidermal growth factor receptor binding
GO:0005168 IPI neurotrophin TRKA receptor binding
GO:0005515 IPI:IEA protein binding
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005768 IDA endosome
GO:0005794 IEA Golgi apparatus
GO:0005829 TAS cytosol
GO:0005886 TAS plasma membrane
GO:0007173 TAS epidermal growth factor receptor signaling pathway
GO:0007265 TAS Ras protein signal transduction
GO:0007267 TAS cell-cell signaling
GO:0007411 TAS axon guidance
GO:0007596 TAS blood coagulation
GO:0008180 IDA COP9 signalosome
GO:0008286 IPI insulin receptor signaling pathway
GO:0008543 TAS fibroblast growth factor receptor signaling pathway
GO:0016032 IEA viral process
GO:0017124 IDA SH3 domain binding
GO:0019901 IPI protein kinase binding
GO:0030168 TAS platelet activation
GO:0031295 TAS T cell costimulation
GO:0031623 IMP receptor internalization
GO:0038095 TAS Fc-epsilon receptor signaling pathway
GO:0038096 TAS Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0042059 TAS negative regulation of epidermal growth factor receptor signaling pathway
GO:0042770 IMP signal transduction in response to DNA damage
GO:0042802 IPI identical protein binding
GO:0043560 IPI insulin receptor substrate binding
GO:0044822 IDA poly(A) RNA binding
GO:0045087 TAS innate immune response
GO:0046875 IPI ephrin receptor binding
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0048015 TAS phosphatidylinositol-mediated signaling
GO:0050900 TAS leukocyte migration
GO:0070062 IDA extracellular vesicular exosome
GO:0070436 IDA Grb2-EGFR complex
GO:0071479 IMP cellular response to ionizing radiation
GO:2000379 IMP positive regulation of reactive oxygen species metabolic process

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000021090 Grb2-002 protein_coding Mus_musculus 0 1389
ENSMUST00000106497 Grb2-001 protein_coding Mus_musculus 0 1375
ENSMUST00000120788 Gm12791-001 processed_pseudogene Mus_musculus 0 887
ENSMUST00000106499 Grb2-003 protein_coding Mus_musculus 0 813
ENSMUST00000106495 Grb2-004 protein_coding Mus_musculus 0 804
ENSMUST00000118484 Gm13542-001 processed_pseudogene Mus_musculus 0 612
ENSMUST00000135065 Grb2-005 protein_coding Mus_musculus 0 446

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