C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: glutamate receptor, metabotropic 8
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000179603 GRM8 9606 - 7:126438598-127253294 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000339582 GRM8-001 126438598-127253294 protein_coding
  ENST00000341617 GRM8-003 126438692-127243219 nonsense_mediated_decay
  ENST00000358373 GRM8-002 126438615-127252381 protein_coding
  ENST00000412160 GRM8-011 127243143-127251026 protein_coding
  ENST00000423518 GRM8-015 127080693-127090918 processed_transcript
  ENST00000444921 GRM8-201 126439119-126533905 protein_coding
  ENST00000448250 GRM8-009 126769921-127118272 processed_transcript
  ENST00000457830 GRM8-012 126904109-127251219 protein_coding
  ENST00000465800 GRM8-013 127084289-127095810 processed_transcript
  ENST00000465844 GRM8-006 127075965-127106652 protein_coding
  ENST00000472701 GRM8-014 126439077-127253093 nonsense_mediated_decay
  ENST00000473254 GRM8-005 127090923-127112286 processed_transcript
  ENST00000480995 GRM8-004 126533051-127112320 processed_transcript
  ENST00000489939 GRM8-007 126438628-126465299 processed_transcript
  ENST00000495315 GRM8-008 126438693-126447188 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeBladderBrainBreastColonHeartKidneyLiverLungOvaryPlacentaTestisENST00000339582ENST00000341617ENST00000358373ENST00000412160ENST00000444921ENST00000448250ENST00000457830ENST00000465800ENST00000480995ENST00000489939ENST00000495315
Transcript ID Adipose Bladder Brain Breast Colon Heart Kidney Liver Lung Ovary Placenta Testis
ENST00000339582 N/A N/A 0.545±0.05 N/A N/A N/A N/A N/A N/A 0.067±0.00 N/A N/A
ENST00000341617 N/A 0.085±0.00 N/A 0.108±0.00 0.399±0.00 N/A N/A N/A N/A 0.140±0.04 N/A N/A
ENST00000358373 N/A N/A 0.858±0.00 0.195±0.00 N/A N/A N/A 0.452±0.00 N/A 0.137±0.00 N/A 0.204±0.00
ENST00000412160 N/A N/A N/A N/A N/A N/A N/A N/A 0.613±0.00 N/A N/A N/A
ENST00000444921 N/A N/A N/A N/A N/A 2.175±0.00 0.188±0.00 0.971±0.00 0.137±0.00 0.267±0.00 0.034±0.00 N/A
ENST00000448250 N/A N/A 0.995±0.00 0.493±0.00 2.541±0.00 N/A 0.269±0.15 0.279±0.00 0.404±0.31 N/A N/A N/A
ENST00000457830 N/A N/A 1.009±0.00 N/A 0.205±0.00 N/A 0.146±0.00 0.067±0.00 0.594±0.00 N/A 0.039±0.01 N/A
ENST00000465800 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.759±0.00
ENST00000480995 N/A N/A N/A N/A N/A N/A 0.551±0.00 N/A N/A 0.082±0.00 0.053±0.00 N/A
ENST00000489939 N/A N/A N/A N/A 0.213±0.00 N/A N/A N/A N/A N/A N/A N/A
ENST00000495315 0.013±0.00 N/A N/A N/A N/A N/A N/A N/A 0.109±0.00 0.167±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0001OL CIL_0001OL_0001 CGP 7:124822386-127253294

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001642 IBA group III metabotropic glutamate receptor activity
GO:0004930 IMP:IEA G-protein coupled receptor activity
GO:0005886 TAS plasma membrane
GO:0005887 IBA integral component of plasma membrane
GO:0007186 IEA G-protein coupled receptor signaling pathway
GO:0007196 IMP adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway
GO:0007601 TAS visual perception
GO:0007608 IEA sensory perception of smell
GO:0008066 IMP glutamate receptor activity
GO:0016021 IEA integral component of membrane
GO:0030818 IDA negative regulation of cAMP biosynthetic process
GO:0042734 IBA presynaptic membrane
GO:0051966 IBA regulation of synaptic transmission, glutamatergic

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000076508 GRM8 (1 of 2) glutamate receptor, metabotropic 8 protein_coding Danio_rerio
ENSDARG00000077654 grm8a glutamate receptor, metabotropic 8a protein_coding Danio_rerio
ENSMUSG00000024211 Grm8 glutamate receptor, metabotropic 8 protein_coding Mus_musculus

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