C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: glutamate receptor, metabotropic 8
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000024211 Grm8 10090 - 6:27275121-28135178 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000090512 Grm8-002 27275612-28126195 protein_coding
  ENSMUST00000115323 Grm8-001 27275121-28134545 protein_coding
  ENSMUST00000115324 Grm8-201 27275128-28126125 protein_coding
  ENSMUST00000131897 Grm8-003 27761343-28133325 protein_coding
  ENSMUST00000132755 Grm8-005 28126064-28133129 protein_coding
  ENSMUST00000146727 Grm8-004 27934377-28135178 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000090512ENSMUST00000115323ENSMUST00000115324ENSMUST00000131897ENSMUST00000132755ENSMUST00000146727
Transcript ID Adipose Adrenal Brain Breast Colon Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000090512 0.066±0.00 0.047±0.02 0.929±0.13 0.046±0.01 N/A 0.013±0.00 0.008±0.01 N/A 0.021±0.01 0.074±0.02 0.012±0.00 0.075±0.05
ENSMUST00000115323 N/A N/A 0.627±0.33 N/A N/A N/A 0.022±0.00 N/A N/A 0.032±0.00 N/A 0.033±0.00
ENSMUST00000115324 0.098±0.00 N/A 0.300±0.00 N/A N/A N/A 0.008±0.00 N/A 0.019±0.00 0.134±0.00 0.014±0.00 0.094±0.00
ENSMUST00000131897 N/A N/A N/A 0.062±0.06 0.139±0.00 0.054±0.00 N/A 0.035±0.00 0.043±0.03 0.266±0.13 N/A 0.037±0.01
ENSMUST00000132755 0.124±0.00 N/A N/A N/A N/A N/A 0.022±0.01 N/A 0.098±0.01 0.113±0.00 0.080±0.00 N/A
ENSMUST00000146727 0.038±0.01 N/A 0.185±0.03 0.032±0.01 N/A N/A 0.006±0.00 0.017±0.00 0.007±0.00 0.070±0.06 0.006±0.00 0.010±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0001OL CIL_0001OL_0002 CGP 6:25743737-28135178

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001642 IDA group III metabotropic glutamate receptor activity
GO:0004930 ISS G-protein coupled receptor activity
GO:0005887 IBA integral component of plasma membrane
GO:0007196 IDA:ISS adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway
GO:0007268 TAS synaptic transmission
GO:0007608 IEA sensory perception of smell
GO:0008066 ISS glutamate receptor activity
GO:0030818 IEA negative regulation of cAMP biosynthetic process
GO:0035249 TAS synaptic transmission, glutamatergic
GO:0042734 IBA presynaptic membrane
GO:0051966 IBA regulation of synaptic transmission, glutamatergic

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000076508 GRM8 (1 of 2) glutamate receptor, metabotropic 8 protein_coding Danio_rerio
ENSDARG00000077654 grm8a glutamate receptor, metabotropic 8a protein_coding Danio_rerio
ENSG00000179603 GRM8 glutamate receptor, metabotropic 8 protein_coding Homo_sapiens

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