C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: chemokine (C-X-C motif) receptor 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000180871 CXCR2 9606 + 2:218125289-218137253 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000318507 CXCR2-001 218126004-218137253 protein_coding
  ENST00000415392 CXCR2-007 218125681-218135216 protein_coding
  ENST00000418878 CXCR2-006 218130850-218134846 protein_coding
  ENST00000428565 CXCR2-005 218129287-218135318 protein_coding
  ENST00000449014 CXCR2-003 218125705-218134846 protein_coding
  ENST00000453237 CXCR2-002 218125289-218135403 protein_coding
  ENST00000454148 CXCR2-004 218126019-218135208 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBreastColonHeartKidneyLiverLungOvaryPlacentaTestisENST00000318507ENST00000428565ENST00000449014ENST00000453237ENST00000454148
Transcript ID Adipose Adrenal Bladder Breast Colon Heart Kidney Liver Lung Ovary Placenta Testis
ENST00000318507 0.345±0.00 0.241±0.00 0.054±0.00 0.135±0.00 0.180±0.04 0.021±0.00 0.017±0.00 0.188±0.11 3.365±2.25 0.114±0.00 0.777±0.00 0.118±0.05
ENST00000428565 N/A N/A N/A N/A N/A 0.204±0.00 N/A 0.114±0.00 N/A N/A N/A N/A
ENST00000449014 N/A N/A N/A N/A N/A N/A N/A N/A N/A 1.826±0.00 N/A N/A
ENST00000453237 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.057±0.00
ENST00000454148 N/A N/A N/A N/A N/A N/A N/A 0.125±0.00 N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007WL CIL_0007WL_0001 VISTA 2:217636448-218238840
CIL_0005VO CIL_0005VO_0001 CGP 2:218034960-218137253
CIL_0005VN CIL_0005VN_0001 CGP 2:218125289-218166995

Gene Ontology
GO IDEvidence TypeGO Description
GO:0002407 TAS dendritic cell chemotaxis
GO:0002438 IEA acute inflammatory response to antigenic stimulus
GO:0002690 IEA positive regulation of leukocyte chemotaxis
GO:0004871 IDA signal transducer activity
GO:0004918 IDA interleukin-8 receptor activity
GO:0004930 IEA G-protein coupled receptor activity
GO:0005515 IPI protein binding
GO:0005622 IDA intracellular
GO:0005886 TAS plasma membrane
GO:0005887 TAS integral component of plasma membrane
GO:0006935 IEA:IDA chemotaxis
GO:0006954 TAS inflammatory response
GO:0006968 IDA cellular defense response
GO:0007165 IDA signal transduction
GO:0007166 IDA cell surface receptor signaling pathway
GO:0007186 IEA G-protein coupled receptor signaling pathway
GO:0007200 IDA phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007204 IEA positive regulation of cytosolic calcium ion concentration
GO:0008284 IDA positive regulation of cell proliferation
GO:0009986 IDA cell surface
GO:0010666 IEA positive regulation of cardiac muscle cell apoptotic process
GO:0016020 IDA membrane
GO:0016021 IEA integral component of membrane
GO:0016494 IEA:IDA C-X-C chemokine receptor activity
GO:0019959 IEA:IPI interleukin-8 binding
GO:0030593 IDA neutrophil chemotaxis
GO:0030901 IEA midbrain development
GO:0031623 IDA receptor internalization
GO:0033030 IEA negative regulation of neutrophil apoptotic process
GO:0038112 IDA interleukin-8-mediated signaling pathway
GO:0042119 IDA neutrophil activation
GO:0042629 IDA mast cell granule
GO:0043066 IEA negative regulation of apoptotic process
GO:0043117 IEA positive regulation of vascular permeability
GO:0045766 IEA positive regulation of angiogenesis
GO:0070098 IEA chemokine-mediated signaling pathway
GO:0072173 IEA metanephric tubule morphogenesis
GO:0090023 IEA positive regulation of neutrophil chemotaxis

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000054975 CXCR1 chemokine (C-X-C motif) receptor 1 protein_coding Danio_rerio
ENSMUSG00000026180 Cxcr2 chemokine (C-X-C motif) receptor 2 protein_coding Mus_musculus

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