C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: siah E3 ubiquitin protein ligase 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000181788 SIAH2 9606 - 3:150741127-150763477 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000312960 SIAH2-001 150741127-150763377 protein_coding
  ENST00000472885 SIAH2-002 150762456-150763477 processed_transcript
  ENST00000482706 SIAH2-003 150742488-150763431 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000312960
Transcript ID Adipose Adrenal Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000312960 5.954±0.00 2.356±0.00 2.638±0.81 1.851±1.12 3.466±1.31 3.392±2.24 10.041±0.43 5.536±4.29 8.307±6.85 2.896±2.29 9.113±8.01 7.076±1.33 5.242±1.59

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0003LA CIL_0003LA_0001 CGP 3:150659885-150763477

Gene Ontology
GO IDEvidence TypeGO Description
GO:0003714 TAS transcription corepressor activity
GO:0004842 IEA ubiquitin-protein transferase activity
GO:0005515 IPI:IEA protein binding
GO:0005634 IEA nucleus
GO:0005737 TAS cytoplasm
GO:0005769 IEA early endosome
GO:0005829 IDA cytosol
GO:0006511 IEA ubiquitin-dependent protein catabolic process
GO:0007049 IEA cell cycle
GO:0007264 TAS small GTPase mediated signal transduction
GO:0007275 IEA multicellular organismal development
GO:0007411 TAS axon guidance
GO:0008270 IEA zinc ion binding
GO:0016567 IEA protein ubiquitination
GO:0016874 IEA ligase activity
GO:0031396 IEA regulation of protein ubiquitination
GO:0031624 IEA ubiquitin conjugating enzyme binding
GO:0043005 IEA neuron projection
GO:0043025 IEA neuronal cell body
GO:0043066 IMP negative regulation of apoptotic process
GO:0043154 IMP negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0044257 IGI cellular protein catabolic process
GO:0090090 IGI negative regulation of canonical Wnt signaling pathway
GO:2001141 TAS regulation of RNA biosynthetic process
GO:2001237 IMP negative regulation of extrinsic apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000044381 siah2l seven in absentia homolog 2 (Drosophila)-like protein_coding Danio_rerio
ENSMUSG00000036432 Siah2 seven in absentia 2 protein_coding Mus_musculus

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