C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: pyrroline-5-carboxylate reductase 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000183010 PYCR1 9606 - 17:81932384-81942412 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000329875 PYCR1-001 81932384-81936879 protein_coding
  ENST00000337943 PYCR1-002 81932384-81937257 protein_coding
  ENST00000402252 PYCR1-003 81932935-81937239 protein_coding
  ENST00000403172 PYCR1-005 81932384-81937328 protein_coding
  ENST00000405481 PYCR1-011 81934364-81937296 protein_coding
  ENST00000577624 PYCR1-009 81934706-81937327 protein_coding
  ENST00000577756 PYCR1-015 81932921-81936869 protein_coding
  ENST00000579366 PYCR1-007 81935048-81941079 protein_coding
  ENST00000579698 PYCR1-012 81934971-81937257 protein_coding
  ENST00000581271 PYCR1-008 81935120-81937662 protein_coding
  ENST00000582198 PYCR1-006 81933356-81942412 protein_coding
  ENST00000583564 PYCR1-014 81935372-81937239 protein_coding
  ENST00000584848 PYCR1-016 81932929-81936775 protein_coding
  ENST00000585215 PYCR1-010 81934446-81937300 protein_coding
  ENST00000585244 PYCR1-013 81935403-81937248 protein_coding
  ENST00000619204 PYCR1-201 81932384-81937328 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000329875ENST00000337943ENST00000402252ENST00000403172ENST00000577756ENST00000579698ENST00000581271ENST00000619204
Transcript ID Adipose Adrenal Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000329875 N/A N/A N/A 1.334±0.00 N/A N/A N/A 1.282±0.00 1.133±0.00 4.811±0.00 12.569±0.91 7.026±3.00 2.064±0.00
ENST00000337943 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 2.146±0.00
ENST00000402252 N/A 2.893±0.00 1.463±0.00 1.372±0.00 2.098±0.00 N/A 2.227±0.00 0.926±0.00 N/A N/A 11.405±2.82 5.774±1.80 2.813±1.09
ENST00000403172 N/A N/A 0.890±0.00 N/A N/A N/A N/A 0.658±0.00 N/A N/A N/A N/A N/A
ENST00000577756 N/A N/A N/A N/A N/A N/A 2.332±0.00 1.311±0.00 N/A N/A 7.450±1.53 N/A 2.230±0.00
ENST00000579698 N/A N/A 1.408±0.00 5.375±0.00 5.513±0.00 N/A 2.905±0.00 2.656±0.00 1.694±0.00 N/A 13.319±0.00 N/A N/A
ENST00000581271 N/A N/A N/A N/A N/A 0.609±0.00 N/A N/A N/A N/A N/A N/A N/A
ENST00000619204 0.425±0.00 2.733±0.00 0.856±0.00 1.505±0.00 2.876±1.58 N/A 0.944±0.00 N/A 1.047±0.00 N/A 7.169±4.43 N/A 4.757±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0006IG CIL_0006IG_0001 CGP 17:81918270-81942412
CIL_0004VN CIL_0004VN_0001 CGP 17:81932384-81947233

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004735 IEA:IDA pyrroline-5-carboxylate reductase activity
GO:0005515 IPI protein binding
GO:0005737 IEA cytoplasm
GO:0005739 IDA mitochondrion
GO:0005759 TAS mitochondrial matrix
GO:0006561 IEA:IDA proline biosynthetic process
GO:0008652 TAS cellular amino acid biosynthetic process
GO:0016616 IEA oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0034599 IMP cellular response to oxidative stress
GO:0034641 TAS cellular nitrogen compound metabolic process
GO:0042802 IPI identical protein binding
GO:0044281 TAS small molecule metabolic process
GO:0046168 IEA glycerol-3-phosphate catabolic process
GO:0051287 IEA NAD binding
GO:0051881 IMP regulation of mitochondrial membrane potential
GO:0055114 IEA oxidation-reduction process
GO:0055129 IEA L-proline biosynthetic process
GO:1903206 IMP negative regulation of hydrogen peroxide-induced cell death

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000053965 pycr1a pyrroline-5-carboxylate reductase 1a protein_coding Danio_rerio
ENSDARG00000086821 pycr1b pyrroline-5-carboxylate reductase 1b protein_coding Danio_rerio
ENSMUSG00000025140 Pycr1 pyrroline-5-carboxylate reductase 1 protein_coding Mus_musculus

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