C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: pyrroline-5-carboxylate reductase 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000025140 Pycr1 10090 - 11:120635712-120643769 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000026133 Pycr1-001 120639416-120643748 protein_coding
  ENSMUST00000133908 Pycr1-004 120642745-120643704 retained_intron
  ENSMUST00000139706 Pycr1-002 120641714-120643769 protein_coding
  ENSMUST00000141254 Pycr1-003 120641224-120643643 protein_coding
  ENSMUST00000151876 Pycr1-005 120641478-120643704 protein_coding
  ENSMUST00000170556 Pycr1-201 120635712-120643670 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000026133ENSMUST00000133908ENSMUST00000139706ENSMUST00000151876ENSMUST00000170556
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000026133 5.120±2.20 0.789±0.23 7.166±0.88 5.072±4.01 3.186±0.44 9.500±1.68 1.130±0.27 0.265±0.06 2.275±2.11 1.862±0.41 1.778±0.17 3.727±1.79 2.419±1.85 0.297±0.19
ENSMUST00000133908 N/A 1.207±0.62 N/A N/A 4.222±0.00 16.611±2.92 N/A N/A N/A N/A N/A 6.955±1.49 N/A N/A
ENSMUST00000139706 N/A N/A N/A N/A N/A N/A 0.761±0.00 0.260±0.06 0.096±0.00 N/A N/A N/A N/A 0.352±0.00
ENSMUST00000151876 N/A N/A N/A N/A N/A N/A N/A N/A 0.146±0.00 N/A N/A N/A N/A 0.105±0.00
ENSMUST00000170556 N/A 0.090±0.00 N/A 0.107±0.00 N/A N/A N/A 0.081±0.04 0.058±0.02 0.134±0.00 0.171±0.02 0.129±0.01 0.226±0.00 0.007±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0006IG CIL_0006IG_0002 CGP 11:120625117-120643769
CIL_0004VN CIL_0004VN_0002 CGP 11:120635712-120648158

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004735 IEA:ISS pyrroline-5-carboxylate reductase activity
GO:0005515 IEA protein binding
GO:0005739 IDA:ISS mitochondrion
GO:0006561 IEA:ISS proline biosynthetic process
GO:0034599 ISS cellular response to oxidative stress
GO:0042802 IEA identical protein binding
GO:0051881 IEA regulation of mitochondrial membrane potential
GO:0055114 IEA oxidation-reduction process
GO:0055129 IEA L-proline biosynthetic process
GO:1903206 IEA negative regulation of hydrogen peroxide-induced cell death

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000053965 pycr1a pyrroline-5-carboxylate reductase 1a protein_coding Danio_rerio
ENSDARG00000086821 pycr1b pyrroline-5-carboxylate reductase 1b protein_coding Danio_rerio
ENSG00000183010 PYCR1 pyrroline-5-carboxylate reductase 1 protein_coding Homo_sapiens

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