C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: NK2 homeobox 5
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000183072 NKX2-5 9606 - 5:173232109-173235357 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000329198 NKX2-5-001 173232109-173235357 protein_coding
  ENST00000424406 NKX2-5-003 173232893-173235264 protein_coding
  ENST00000517440 NKX2-5-002 173234048-173235311 protein_coding
  ENST00000521848 NKX2-5-004 173232895-173235206 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdrenalBrainBreastHeartMusclePlacentaTestisENST00000329198ENST00000424406ENST00000517440ENST00000521848
Transcript ID Adrenal Brain Breast Heart Muscle Placenta Testis
ENST00000329198 N/A 0.103±0.00 0.088±0.00 17.496±15.23 0.023±0.00 0.532±0.10 0.267±0.16
ENST00000424406 N/A N/A N/A 11.178±0.00 N/A N/A 0.095±0.00
ENST00000517440 0.219±0.00 N/A N/A 8.869±0.00 N/A N/A N/A
ENST00000521848 N/A 0.113±0.00 N/A 1.398±0.00 N/A 0.168±0.00 0.312±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_000915 CIL_000915_0001 VISTA 5:172905793-173506594
CIL_0008HF CIL_0008HF_0001 VISTA 5:172963494-173565311
CIL_00023O CIL_00023O_0001 CGP 5:173144442-173235357

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IMP negative regulation of transcription from RNA polymerase II promoter
GO:0000978 IMP RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077 IMP RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001104 IEA RNA polymerase II transcription cofactor activity
GO:0001190 IEA RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription
GO:0001570 ISS vasculogenesis
GO:0001947 ISS heart looping
GO:0003007 ISS heart morphogenesis
GO:0003148 IMP outflow tract septum morphogenesis
GO:0003151 IEA outflow tract morphogenesis
GO:0003161 IMP cardiac conduction system development
GO:0003162 IEA atrioventricular node development
GO:0003166 IEA bundle of His development
GO:0003168 IEA Purkinje myocyte differentiation
GO:0003208 IEA cardiac ventricle morphogenesis
GO:0003211 IEA cardiac ventricle formation
GO:0003221 IMP right ventricular cardiac muscle tissue morphogenesis
GO:0003222 IEA ventricular trabecula myocardium morphogenesis
GO:0003278 IEA apoptotic process involved in heart morphogenesis
GO:0003285 IMP septum secundum development
GO:0003342 IEA proepicardium development
GO:0003350 IEA pulmonary myocardium development
GO:0003677 IDA:IEA DNA binding
GO:0003682 IDA chromatin binding
GO:0003700 IDA sequence-specific DNA binding transcription factor activity
GO:0003705 IEA RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005667 IC transcription factor complex
GO:0005737 IEA cytoplasm
GO:0006357 IEA regulation of transcription from RNA polymerase II promoter
GO:0006366 IEA transcription from RNA polymerase II promoter
GO:0007507 IEA heart development
GO:0007512 IMP adult heart development
GO:0008134 IPI transcription factor binding
GO:0008284 ISS positive regulation of cell proliferation
GO:0010628 IEA positive regulation of gene expression
GO:0010667 IMP negative regulation of cardiac muscle cell apoptotic process
GO:0010735 ISS positive regulation of transcription via serum response element binding
GO:0010736 ISS serum response element binding
GO:0010765 ISS positive regulation of sodium ion transport
GO:0010832 IMP negative regulation of myotube differentiation
GO:0030097 ISS hemopoiesis
GO:0030154 ISS cell differentiation
GO:0030509 IEA BMP signaling pathway
GO:0030878 IMP thyroid gland development
GO:0035050 ISS embryonic heart tube development
GO:0042803 IEA protein homodimerization activity
GO:0043066 ISS negative regulation of apoptotic process
GO:0043565 IDA sequence-specific DNA binding
GO:0044212 IDA transcription regulatory region DNA binding
GO:0045214 IEA sarcomere organization
GO:0045666 IMP positive regulation of neuron differentiation
GO:0045823 ISS positive regulation of heart contraction
GO:0045892 ISS negative regulation of transcription, DNA-templated
GO:0045893 IDA positive regulation of transcription, DNA-templated
GO:0045944 IGI positive regulation of transcription from RNA polymerase II promoter
GO:0046982 ISS protein heterodimerization activity
GO:0048536 IMP spleen development
GO:0048738 IEA cardiac muscle tissue development
GO:0051891 ISS positive regulation of cardioblast differentiation
GO:0055005 IEA ventricular cardiac myofibril assembly
GO:0055007 ISS cardiac muscle cell differentiation
GO:0055008 IMP cardiac muscle tissue morphogenesis
GO:0055014 ISS atrial cardiac muscle cell development
GO:0055015 ISS ventricular cardiac muscle cell development
GO:0055117 ISS regulation of cardiac muscle contraction
GO:0060037 ISS pharyngeal system development
GO:0060038 IEA cardiac muscle cell proliferation
GO:0060043 IEA regulation of cardiac muscle cell proliferation
GO:0060047 IEA heart contraction
GO:0060048 IEA cardiac muscle contraction
GO:0060070 IEA canonical Wnt signaling pathway
GO:0060261 ISS positive regulation of transcription initiation from RNA polymerase II promoter
GO:0060347 IEA heart trabecula formation
GO:0060412 IMP ventricular septum morphogenesis
GO:0060413 IMP atrial septum morphogenesis
GO:0060928 IEA atrioventricular node cell development
GO:0060929 IEA atrioventricular node cell fate commitment
GO:0060971 IEA embryonic heart tube left/right pattern formation
GO:0072358 IEA cardiovascular system development
GO:0090090 ISS negative regulation of canonical Wnt signaling pathway
GO:1901387 ISS positive regulation of voltage-gated calcium channel activity

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000018004 nkx2.5 NK2 transcription factor related 5 protein_coding Danio_rerio
ENSMUSG00000015579 Nkx2-5 NK2 homeobox 5 protein_coding Mus_musculus

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