C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: NK2 homeobox 5
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000015579 Nkx2-5 10090 - 17:26838664-26841565 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000015723 Nkx2-5-001 26838664-26841565 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdrenalBrainBreastHeartKidneyLiverLungOvaryPlacentaENSMUST00000015723
Transcript ID Adrenal Brain Breast Heart Kidney Liver Lung Ovary Placenta
ENSMUST00000015723 0.042±0.01 0.015±0.00 0.020±0.00 34.245±7.21 0.026±0.01 0.012±0.00 0.632±0.13 0.041±0.02 0.170±0.09

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_000915 CIL_000915_0002 VISTA 17:26527896-27128643
CIL_0008HF CIL_0008HF_0002 VISTA 17:26563571-27166666
CIL_00023O CIL_00023O_0002 CGP 17:26781079-26841565

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IDA negative regulation of transcription from RNA polymerase II promoter
GO:0000978 IEA RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077 IEA RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001104 IMP RNA polymerase II transcription cofactor activity
GO:0001190 IMP RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription
GO:0001570 IMP vasculogenesis
GO:0001947 IMP heart looping
GO:0003007 IMP heart morphogenesis
GO:0003148 IEA outflow tract septum morphogenesis
GO:0003151 IMP outflow tract morphogenesis
GO:0003161 IGI cardiac conduction system development
GO:0003162 IMP atrioventricular node development
GO:0003166 IGI bundle of His development
GO:0003168 IMP Purkinje myocyte differentiation
GO:0003208 IMP cardiac ventricle morphogenesis
GO:0003211 IGI cardiac ventricle formation
GO:0003221 IEA right ventricular cardiac muscle tissue morphogenesis
GO:0003222 IMP ventricular trabecula myocardium morphogenesis
GO:0003278 IMP apoptotic process involved in heart morphogenesis
GO:0003285 IEA septum secundum development
GO:0003342 IMP proepicardium development
GO:0003350 IMP pulmonary myocardium development
GO:0003677 IDA DNA binding
GO:0003682 IDA chromatin binding
GO:0003700 IDA sequence-specific DNA binding transcription factor activity
GO:0003705 IDA RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005667 IDA transcription factor complex
GO:0005737 IDA cytoplasm
GO:0006357 IDA regulation of transcription from RNA polymerase II promoter
GO:0006366 IMP transcription from RNA polymerase II promoter
GO:0007492 TAS endoderm development
GO:0007507 IMP heart development
GO:0007512 IMP adult heart development
GO:0008134 IEA transcription factor binding
GO:0008284 IGI positive regulation of cell proliferation
GO:0010628 IDA positive regulation of gene expression
GO:0010667 IMP negative regulation of cardiac muscle cell apoptotic process
GO:0010735 IDA positive regulation of transcription via serum response element binding
GO:0010736 IDA serum response element binding
GO:0010765 IMP positive regulation of sodium ion transport
GO:0010832 IEA negative regulation of myotube differentiation
GO:0030097 IMP hemopoiesis
GO:0030154 IGI cell differentiation
GO:0030509 IDA BMP signaling pathway
GO:0030878 IMP thyroid gland development
GO:0035050 IGI embryonic heart tube development
GO:0042803 IDA protein homodimerization activity
GO:0043066 IGI negative regulation of apoptotic process
GO:0043565 IEA sequence-specific DNA binding
GO:0043586 TAS tongue development
GO:0044212 IEA transcription regulatory region DNA binding
GO:0045214 IGI sarcomere organization
GO:0045666 IEA positive regulation of neuron differentiation
GO:0045823 IMP positive regulation of heart contraction
GO:0045893 IDA positive regulation of transcription, DNA-templated
GO:0045944 IGI positive regulation of transcription from RNA polymerase II promoter
GO:0046982 IPI protein heterodimerization activity
GO:0048536 IGI spleen development
GO:0048738 IMP cardiac muscle tissue development
GO:0051891 IMP positive regulation of cardioblast differentiation
GO:0055005 IMP ventricular cardiac myofibril assembly
GO:0055007 IMP cardiac muscle cell differentiation
GO:0055008 IEA cardiac muscle tissue morphogenesis
GO:0055014 TAS atrial cardiac muscle cell development
GO:0055015 TAS ventricular cardiac muscle cell development
GO:0055117 IMP regulation of cardiac muscle contraction
GO:0060037 IGI pharyngeal system development
GO:0060038 IGI cardiac muscle cell proliferation
GO:0060043 IDA regulation of cardiac muscle cell proliferation
GO:0060047 IGI heart contraction
GO:0060048 IMP cardiac muscle contraction
GO:0060070 IDA canonical Wnt signaling pathway
GO:0060261 IDA positive regulation of transcription initiation from RNA polymerase II promoter
GO:0060347 IMP heart trabecula formation
GO:0060412 IEA ventricular septum morphogenesis
GO:0060413 IEA atrial septum morphogenesis
GO:0060928 IMP atrioventricular node cell development
GO:0060929 IMP atrioventricular node cell fate commitment
GO:0060971 IMP embryonic heart tube left/right pattern formation
GO:0072358 IGI cardiovascular system development
GO:0090090 IDA negative regulation of canonical Wnt signaling pathway
GO:1901387 IMP positive regulation of voltage-gated calcium channel activity

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000018004 nkx2.5 NK2 transcription factor related 5 protein_coding Danio_rerio
ENSG00000183072 NKX2-5 NK2 homeobox 5 protein_coding Homo_sapiens

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