C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: interleukin-1 receptor-associated kinase 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000184216 IRAK1 9606 - X:154010500-154019980 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000369973 IRAK1-004 154011688-154019897 nonsense_mediated_decay
  ENST00000369974 IRAK1-001 154010506-154019876 protein_coding
  ENST00000369980 IRAK1-012 154010500-154019980 protein_coding
  ENST00000393687 IRAK1-002 154011859-154019812 protein_coding
  ENST00000429936 IRAK1-020 154011859-154019812 protein_coding
  ENST00000437278 IRAK1-003 154011827-154016994 protein_coding
  ENST00000443220 IRAK1-005 154013043-154018638 protein_coding
  ENST00000444230 IRAK1-017 154010520-154019800 protein_coding
  ENST00000444254 IRAK1-010 154011731-154014246 protein_coding
  ENST00000455690 IRAK1-016 154011563-154016073 protein_coding
  ENST00000463031 IRAK1-018 154018346-154018945 retained_intron
  ENST00000467236 IRAK1-006 154013336-154014377 processed_transcript
  ENST00000477274 IRAK1-019 154010722-154018647 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000369974ENST00000369980ENST00000393687ENST00000429936ENST00000444230ENST00000444254ENST00000477274
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000369974 22.419±0.00 20.899±0.00 0.325±0.00 1.556±1.19 9.723±8.19 7.913±0.00 2.525±0.00 1.895±0.00 6.693±0.00 2.962±0.00 8.362±0.00 12.282±0.00 6.555±2.71 6.070±0.00
ENST00000369980 25.010±0.00 18.615±0.00 0.500±0.00 2.941±2.53 18.977±0.00 4.257±2.43 5.410±0.00 21.897±0.00 5.128±4.70 7.879±0.00 11.380±0.00 13.787±8.49 16.660±0.51 6.875±0.00
ENST00000393687 N/A N/A 0.896±0.00 N/A N/A 1.235±0.00 N/A N/A 1.347±0.00 2.253±0.00 N/A 37.341±35.81 24.060±0.00 12.734±0.00
ENST00000429936 N/A N/A N/A N/A 1.194±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000444230 N/A N/A 1.131±0.00 N/A N/A N/A N/A N/A 10.013±0.00 N/A 2.486±0.00 N/A N/A N/A
ENST00000444254 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 2.893±0.00 N/A N/A N/A
ENST00000477274 N/A N/A N/A 7.936±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007GC CIL_0007GC_0002 CGP X:154010500-154097755

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000187 TAS activation of MAPK activity
GO:0001959 IMP regulation of cytokine-mediated signaling pathway
GO:0002224 TAS toll-like receptor signaling pathway
GO:0002755 TAS MyD88-dependent toll-like receptor signaling pathway
GO:0002756 TAS MyD88-independent toll-like receptor signaling pathway
GO:0004672 IDA:IEA protein kinase activity
GO:0004674 NAS protein serine/threonine kinase activity
GO:0004704 TAS NF-kappaB-inducing kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0004842 TAS ubiquitin-protein transferase activity
GO:0005149 IEA interleukin-1 receptor binding
GO:0005515 IEA protein binding
GO:0005524 IEA ATP binding
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005811 ISS lipid particle
GO:0005829 TAS cytosol
GO:0005886 TAS plasma membrane
GO:0006468 TAS:IEA protein phosphorylation
GO:0007165 IEA signal transduction
GO:0007178 NAS transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0007250 IDA activation of NF-kappaB-inducing kinase activity
GO:0007254 TAS JNK cascade
GO:0007568 IEA aging
GO:0008152 IEA metabolic process
GO:0010008 TAS endosome membrane
GO:0016020 IEA membrane
GO:0016301 IDA kinase activity
GO:0016567 TAS protein ubiquitination
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0019221 IEA cytokine-mediated signaling pathway
GO:0031072 IEA heat shock protein binding
GO:0031663 IMP lipopolysaccharide-mediated signaling pathway
GO:0032088 IMP negative regulation of NF-kappaB transcription factor activity
GO:0032494 IEA response to peptidoglycan
GO:0032496 IMP response to lipopolysaccharide
GO:0034134 IMP toll-like receptor 2 signaling pathway
GO:0034138 TAS toll-like receptor 3 signaling pathway
GO:0034142 TAS toll-like receptor 4 signaling pathway
GO:0034146 TAS toll-like receptor 5 signaling pathway
GO:0034162 TAS toll-like receptor 9 signaling pathway
GO:0034166 TAS toll-like receptor 10 signaling pathway
GO:0034605 IEA cellular response to heat
GO:0035666 TAS TRIF-dependent toll-like receptor signaling pathway
GO:0035872 TAS nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO:0038123 TAS toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124 TAS toll-like receptor TLR6:TLR2 signaling pathway
GO:0042803 IPI protein homodimerization activity
GO:0043066 TAS negative regulation of apoptotic process
GO:0043123 IMP positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087 TAS innate immune response
GO:0045323 NAS interleukin-1 receptor complex
GO:0045893 NAS positive regulation of transcription, DNA-templated
GO:0046777 IDA protein autophosphorylation
GO:0046982 IPI protein heterodimerization activity
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0048661 IEA positive regulation of smooth muscle cell proliferation
GO:0051092 IDA positive regulation of NF-kappaB transcription factor activity
GO:0051259 IMP protein oligomerization
GO:0051403 TAS stress-activated MAPK cascade
GO:0070423 TAS nucleotide-binding oligomerization domain containing signaling pathway
GO:0070498 IMP interleukin-1-mediated signaling pathway
GO:0070555 IMP response to interleukin-1
GO:0071222 IEA cellular response to lipopolysaccharide
GO:0071456 IEA cellular response to hypoxia

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000025949 irak1 interleukin-1 receptor-associated kinase 1 protein_coding Danio_rerio
ENSMUSG00000031392 Irak1 interleukin-1 receptor-associated kinase 1 protein_coding Mus_musculus

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