C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: interleukin-1 receptor-associated kinase 1
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000369974 IRAK1-001 ENSG00000184216 9606 - X:154010506-154019876 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000369974
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000369974 22.419±0.00 20.899±0.00 0.325±0.00 1.556±1.19 9.723±8.19 7.913±0.00 2.525±0.00 1.895±0.00 6.693±0.00 2.962±0.00 8.362±0.00 12.282±0.00 6.555±2.71 6.070±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007GC CIL_0007GC_0002 CGP X:154010500-154097755

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000187 TAS activation of MAPK activity
GO:0001959 IMP regulation of cytokine-mediated signaling pathway
GO:0002224 TAS toll-like receptor signaling pathway
GO:0002755 TAS MyD88-dependent toll-like receptor signaling pathway
GO:0002756 TAS MyD88-independent toll-like receptor signaling pathway
GO:0004672 IDA:IEA protein kinase activity
GO:0004674 NAS protein serine/threonine kinase activity
GO:0004704 TAS NF-kappaB-inducing kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0004842 TAS ubiquitin-protein transferase activity
GO:0005515 IPI:IEA protein binding
GO:0005524 IEA ATP binding
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005811 ISS lipid particle
GO:0005829 TAS cytosol
GO:0005886 TAS plasma membrane
GO:0006468 TAS:IEA protein phosphorylation
GO:0007165 NAS:IEA signal transduction
GO:0007178 NAS transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0007250 IDA activation of NF-kappaB-inducing kinase activity
GO:0007254 TAS JNK cascade
GO:0010008 TAS endosome membrane
GO:0016301 IDA kinase activity
GO:0016567 TAS protein ubiquitination
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0031663 IMP lipopolysaccharide-mediated signaling pathway
GO:0032088 IMP negative regulation of NF-kappaB transcription factor activity
GO:0032496 IMP response to lipopolysaccharide
GO:0034134 IMP toll-like receptor 2 signaling pathway
GO:0034138 TAS toll-like receptor 3 signaling pathway
GO:0034142 TAS toll-like receptor 4 signaling pathway
GO:0034146 TAS toll-like receptor 5 signaling pathway
GO:0034162 TAS toll-like receptor 9 signaling pathway
GO:0034166 TAS toll-like receptor 10 signaling pathway
GO:0035666 TAS TRIF-dependent toll-like receptor signaling pathway
GO:0035872 TAS nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO:0038123 TAS toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124 TAS toll-like receptor TLR6:TLR2 signaling pathway
GO:0042803 IPI protein homodimerization activity
GO:0043066 TAS negative regulation of apoptotic process
GO:0043123 IMP positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087 TAS innate immune response
GO:0045323 NAS interleukin-1 receptor complex
GO:0045893 NAS positive regulation of transcription, DNA-templated
GO:0046777 IDA protein autophosphorylation
GO:0046982 IPI protein heterodimerization activity
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0051092 IDA positive regulation of NF-kappaB transcription factor activity
GO:0051259 IMP protein oligomerization
GO:0051403 TAS stress-activated MAPK cascade
GO:0070423 TAS nucleotide-binding oligomerization domain containing signaling pathway
GO:0070498 IMP interleukin-1-mediated signaling pathway
GO:0070555 IMP response to interleukin-1

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000114353 Irak1-008 protein_coding Mus_musculus 0 1657
ENSMUST00000114360 Irak1-006 protein_coding Mus_musculus 0 1423
ENSMUST00000068286 Irak1-005 protein_coding Mus_musculus 0 1423
ENSMUST00000114352 Irak1-004 protein_coding Mus_musculus 0 1423
ENSMUST00000033769 Irak1-003 protein_coding Mus_musculus 0 1413
ENSMUST00000114354 Irak1-001 protein_coding Mus_musculus 0 1413
ENSMUST00000101458 Irak1-009 protein_coding Mus_musculus 0 1375
ENSMUST00000149871 Irak1-007 retained_intron Mus_musculus 0 1166
ENSMUST00000145677 Irak1-012 retained_intron Mus_musculus 0 702
ENSMUST00000148706 Irak1-002 retained_intron Mus_musculus 0 638
ENSMUST00000128759 Irak1-011 retained_intron Mus_musculus 0 484
ENSMUST00000149809 Irak1-013 processed_transcript Mus_musculus 0 403
ENSMUST00000124580 Irak1-016 protein_coding Mus_musculus 0 353
ENSMUST00000132144 Irak1-010 protein_coding Mus_musculus 0 267

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