C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: interleukin-1 receptor-associated kinase 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000031392 Irak1 10090 - X:74013914-74023918 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000033769 Irak1-003 74014971-74023913 protein_coding
  ENSMUST00000068286 Irak1-005 74013926-74023915 protein_coding
  ENSMUST00000101458 Irak1-009 74015440-74023745 protein_coding
  ENSMUST00000114352 Irak1-004 74013918-74023915 protein_coding
  ENSMUST00000114353 Irak1-008 74015440-74023745 protein_coding
  ENSMUST00000114354 Irak1-001 74013914-74023918 protein_coding
  ENSMUST00000114360 Irak1-006 74013926-74023915 protein_coding
  ENSMUST00000124417 Irak1-017 74022229-74022944 protein_coding
  ENSMUST00000124580 Irak1-016 74022187-74023173 protein_coding
  ENSMUST00000126583 Irak1-019 74017130-74022496 protein_coding
  ENSMUST00000128436 Irak1-021 74015372-74019941 protein_coding
  ENSMUST00000128759 Irak1-011 74023095-74023831 retained_intron
  ENSMUST00000132144 Irak1-010 74021000-74023091 protein_coding
  ENSMUST00000138397 Irak1-022 74016548-74020988 protein_coding
  ENSMUST00000140130 Irak1-018 74021000-74022651 retained_intron
  ENSMUST00000144353 Irak1-014 74022746-74023508 processed_transcript
  ENSMUST00000145677 Irak1-012 74022618-74023808 retained_intron
  ENSMUST00000146210 Irak1-015 74022633-74023376 retained_intron
  ENSMUST00000148317 Irak1-020 74015358-74018334 protein_coding
  ENSMUST00000148706 Irak1-002 74014806-74023826 retained_intron
  ENSMUST00000149809 Irak1-013 74022238-74023727 processed_transcript
  ENSMUST00000149871 Irak1-007 74014806-74023826 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000033769ENSMUST00000068286ENSMUST00000101458ENSMUST00000114352ENSMUST00000114354ENSMUST00000114360ENSMUST00000128436ENSMUST00000132144ENSMUST00000145677ENSMUST00000148706ENSMUST00000149871
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000033769 9.116±0.68 N/A N/A 5.001±0.00 7.694±0.57 N/A 5.429±0.38 5.298±1.03 3.117±0.63 N/A N/A 17.265±8.00 5.376±3.97 0.819±0.00
ENSMUST00000068286 N/A 35.075±7.55 N/A N/A 19.775±5.91 9.835±0.00 N/A N/A N/A N/A N/A 27.159±5.29 N/A 0.979±0.07
ENSMUST00000101458 N/A N/A N/A 8.247±0.00 N/A N/A N/A N/A N/A N/A N/A 14.482±0.00 8.062±0.00 0.774±0.29
ENSMUST00000114352 N/A N/A 10.416±0.17 3.540±1.38 5.268±0.00 7.120±0.00 N/A N/A 4.591±1.22 N/A 5.068±0.00 10.356±1.87 4.061±0.98 0.200±0.00
ENSMUST00000114354 14.967±2.85 24.252±2.04 14.506±2.77 5.541±2.35 13.289±1.16 9.650±1.64 10.114±1.81 10.889±0.60 7.123±1.65 12.044±1.69 10.011±2.31 12.239±2.87 6.295±4.63 1.265±0.45
ENSMUST00000114360 19.475±4.17 29.664±0.00 N/A N/A 19.191±4.59 18.039±3.63 6.634±1.88 10.672±3.43 8.816±1.11 16.658±1.34 N/A 29.386±9.46 N/A 1.422±0.63
ENSMUST00000128436 N/A N/A N/A 32.027±0.00 N/A N/A N/A N/A N/A N/A N/A 77.703±0.00 42.696±16.19 N/A
ENSMUST00000132144 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 13.701±0.00
ENSMUST00000145677 N/A 87.378±29.99 N/A N/A 41.791±11.57 21.441±4.36 N/A N/A 10.383±2.23 17.265±2.73 N/A 46.192±13.30 N/A N/A
ENSMUST00000148706 N/A N/A N/A 5.390±0.00 N/A N/A N/A N/A N/A N/A N/A N/A 3.564±0.00 N/A
ENSMUST00000149871 N/A N/A N/A N/A 6.060±0.00 N/A N/A N/A 3.222±0.35 6.383±0.79 N/A 10.076±0.07 2.952±1.40 0.682±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007F4 CIL_0007F4_0002 CGP X:73942792-74023918
CIL_0007GC CIL_0007GC_0003 CGP X:74013914-74135363

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001959 IEA regulation of cytokine-mediated signaling pathway
GO:0004672 IDA protein kinase activity
GO:0004674 IEA protein serine/threonine kinase activity
GO:0005149 IPI interleukin-1 receptor binding
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005634 IEA nucleus
GO:0005737 IEA cytoplasm
GO:0005811 IDA lipid particle
GO:0007250 IEA activation of NF-kappaB-inducing kinase activity
GO:0007254 IEA JNK cascade
GO:0007568 IEA aging
GO:0016020 IEA membrane
GO:0016301 IEA kinase activity
GO:0019221 IDA cytokine-mediated signaling pathway
GO:0031072 IEA heat shock protein binding
GO:0031663 IDA lipopolysaccharide-mediated signaling pathway
GO:0032088 IEA negative regulation of NF-kappaB transcription factor activity
GO:0032494 IDA response to peptidoglycan
GO:0032496 IDA response to lipopolysaccharide
GO:0034134 IDA toll-like receptor 2 signaling pathway
GO:0034142 IDA toll-like receptor 4 signaling pathway
GO:0034605 IEA cellular response to heat
GO:0042803 IEA protein homodimerization activity
GO:0043123 IEA positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043406 IMP positive regulation of MAP kinase activity
GO:0043507 IMP positive regulation of JUN kinase activity
GO:0045087 IEP innate immune response
GO:0045892 IMP negative regulation of transcription, DNA-templated
GO:0046777 IDA protein autophosphorylation
GO:0046982 IEA protein heterodimerization activity
GO:0048661 IEA positive regulation of smooth muscle cell proliferation
GO:0051092 IDA positive regulation of NF-kappaB transcription factor activity
GO:0051259 IEA protein oligomerization
GO:0070498 IDA interleukin-1-mediated signaling pathway
GO:0070555 IEA response to interleukin-1
GO:0071222 IEA cellular response to lipopolysaccharide
GO:0071456 IEA cellular response to hypoxia
GO:0090370 IMP negative regulation of cholesterol efflux

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000025949 irak1 interleukin-1 receptor-associated kinase 1 protein_coding Danio_rerio
ENSG00000184216 IRAK1 interleukin-1 receptor-associated kinase 1 protein_coding Homo_sapiens

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