C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: diacylglycerol O-acyltransferase 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000185000 DGAT1 9606 - 8:144314584-144326910 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000332324 DGAT1-004 144316325-144326910 protein_coding
  ENST00000524844 DGAT1-007 144317075-144318321 processed_transcript
  ENST00000524965 DGAT1-006 144316320-144318724 retained_intron
  ENST00000525371 DGAT1-002 144318094-144326667 retained_intron
  ENST00000527885 DGAT1-008 144316843-144317633 retained_intron
  ENST00000528718 DGAT1-001 144314584-144326910 protein_coding
  ENST00000531896 DGAT1-003 144317917-144326674 retained_intron
  ENST00000620428 DGAT1-009 144314590-144315138 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000332324ENST00000524844ENST00000524965ENST00000528718ENST00000531896
Transcript ID Adipose Adrenal Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000332324 N/A N/A N/A N/A N/A N/A N/A 13.354±0.00 N/A N/A N/A N/A N/A
ENST00000524844 N/A N/A N/A N/A N/A N/A N/A 11.235±0.00 N/A N/A N/A N/A N/A
ENST00000524965 28.446±0.00 23.808±0.00 6.923±4.46 38.155±36.28 18.544±15.51 N/A 10.612±5.82 13.594±0.00 25.152±0.00 N/A 42.255±10.62 23.992±1.38 43.557±0.74
ENST00000528718 N/A N/A 4.030±0.00 8.211±7.17 1.072±0.00 0.572±0.00 5.896±0.00 2.212±1.22 N/A 2.940±0.00 10.321±1.55 N/A N/A
ENST00000531896 N/A N/A N/A N/A N/A N/A 4.033±0.00 N/A N/A N/A 48.434±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007SS CIL_0007SS_0001 VISTA 8:143880613-144482307
CIL_00064A CIL_00064A_0002 CGP 8:144266560-144314722
CIL_00026U CIL_00026U_0001 CGP 8:144291591-144326910
CIL_00026R CIL_00026R_0001 CGP 8:144314584-144336281

Gene Ontology
GO IDEvidence TypeGO Description
GO:0003846 IEA 2-acylglycerol O-acyltransferase activity
GO:0004144 IDA diacylglycerol O-acyltransferase activity
GO:0005515 IPI protein binding
GO:0005789 TAS endoplasmic reticulum membrane
GO:0006641 TAS triglyceride metabolic process
GO:0006644 TAS phospholipid metabolic process
GO:0016020 IEA membrane
GO:0016021 ISS integral component of membrane
GO:0016310 IEA phosphorylation
GO:0016746 TAS transferase activity, transferring acyl groups
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0019432 IDA triglyceride biosynthetic process
GO:0019915 ISS lipid storage
GO:0034379 IMP very-low-density lipoprotein particle assembly
GO:0035336 ISS long-chain fatty-acyl-CoA metabolic process
GO:0036155 TAS acylglycerol acyl-chain remodeling
GO:0042572 IEA retinol metabolic process
GO:0043231 IEA intracellular membrane-bounded organelle
GO:0044255 TAS cellular lipid metabolic process
GO:0044281 TAS small molecule metabolic process
GO:0046339 ISS diacylglycerol metabolic process
GO:0046474 TAS glycerophospholipid biosynthetic process
GO:0050252 IEA retinol O-fatty-acyltransferase activity
GO:0055089 IEA fatty acid homeostasis

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000031465 dgat1a diacylglycerol O-acyltransferase homolog 1a (mouse) protein_coding Danio_rerio
ENSDARG00000054914 dgat1b diacylglycerol O-acyltransferase homolog 1b (mouse) protein_coding Danio_rerio
ENSMUSG00000022555 Dgat1 diacylglycerol O-acyltransferase 1 protein_coding Mus_musculus

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