C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: phosphodiesterase 2A, cGMP-stimulated
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000186642 PDE2A 9606 - 11:72576141-72674591 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000334456 PDE2A-001 72576141-72674453 protein_coding
  ENST00000376450 PDE2A-003 72576142-72642431 protein_coding
  ENST00000418754 PDE2A-010 72577211-72674408 protein_coding
  ENST00000420501 PDE2A-004 72578910-72582369 protein_coding
  ENST00000441209 PDE2A-005 72579281-72584473 protein_coding
  ENST00000444035 PDE2A-201 72576142-72642460 protein_coding
  ENST00000475807 PDE2A-008 72584551-72590419 protein_coding
  ENST00000485058 PDE2A-007 72597510-72643131 processed_transcript
  ENST00000490749 PDE2A-006 72590933-72596626 retained_intron
  ENST00000535701 PDE2A-015 72597604-72674422 nonsense_mediated_decay
  ENST00000536308 PDE2A-021 72590199-72642411 nonsense_mediated_decay
  ENST00000536458 PDE2A-016 72642254-72658121 protein_coding
  ENST00000536918 PDE2A-027 72577545-72579505 retained_intron
  ENST00000537631 PDE2A-020 72596624-72636130 nonsense_mediated_decay
  ENST00000538299 PDE2A-024 72585426-72590021 protein_coding
  ENST00000538749 PDE2A-017 72591349-72643618 protein_coding
  ENST00000539367 PDE2A-002 72576142-72642443 nonsense_mediated_decay
  ENST00000540345 PDE2A-012 72577296-72669064 protein_coding
  ENST00000540380 PDE2A-013 72596629-72674591 processed_transcript
  ENST00000541998 PDE2A-022 72591178-72642426 nonsense_mediated_decay
  ENST00000542223 PDE2A-025 72579549-72583563 protein_coding
  ENST00000542969 PDE2A-009 72605138-72674433 protein_coding
  ENST00000543575 PDE2A-023 72590507-72642422 nonsense_mediated_decay
  ENST00000543750 PDE2A-019 72590479-72642460 nonsense_mediated_decay
  ENST00000544239 PDE2A-026 72578961-72579896 retained_intron
  ENST00000544570 PDE2A-018 72577154-72642460 protein_coding
  ENST00000546038 PDE2A-014 72631082-72674450 nonsense_mediated_decay

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartLiverLungMuscleOvaryPlacentaTestisENST00000334456ENST00000376450ENST00000418754ENST00000420501ENST00000444035ENST00000536918ENST00000539367ENST00000540345ENST00000542223ENST00000544570
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Liver Lung Muscle Ovary Placenta Testis
ENST00000334456 N/A N/A N/A 3.876±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000376450 22.034±0.00 N/A N/A N/A 4.144±0.00 N/A N/A 0.982±0.00 N/A 1.073±0.00 0.226±0.00 N/A N/A
ENST00000418754 N/A N/A N/A N/A 0.500±0.00 N/A N/A N/A N/A N/A 0.289±0.07 N/A N/A
ENST00000420501 N/A N/A N/A N/A N/A N/A N/A N/A 1.830±0.00 N/A N/A N/A N/A
ENST00000444035 52.109±0.00 3.515±0.00 N/A N/A 13.463±0.00 0.853±0.00 4.433±0.00 2.518±0.00 N/A N/A 2.195±0.63 0.803±0.45 N/A
ENST00000536918 N/A N/A N/A N/A 2.393±0.00 N/A N/A N/A N/A N/A N/A 1.611±0.00 N/A
ENST00000539367 N/A 5.508±0.00 N/A 6.650±0.00 N/A 8.167±0.00 N/A N/A N/A N/A N/A N/A N/A
ENST00000540345 N/A N/A 1.403±0.00 11.246±0.00 N/A 0.936±0.00 N/A 2.768±0.00 0.416±0.00 N/A N/A N/A N/A
ENST00000542223 N/A N/A N/A 40.759±0.00 3.064±0.00 N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000544570 N/A N/A N/A N/A 0.477±0.00 N/A 1.579±0.00 1.023±0.00 N/A N/A N/A N/A 1.325±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008XL CIL_0008XL_0001 VISTA 11:72069476-72670457

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IDA negative regulation of transcription from RNA polymerase II promoter
GO:0004112 IDA cyclic-nucleotide phosphodiesterase activity
GO:0004114 IEA 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0004118 IDA cGMP-stimulated cyclic-nucleotide phosphodiesterase activity
GO:0005262 TAS calcium channel activity
GO:0005515 IPI:IEA protein binding
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005759 ISS mitochondrial matrix
GO:0005783 ISS endoplasmic reticulum
GO:0005794 ISS Golgi apparatus
GO:0005829 IDA cytosol
GO:0005886 IDA plasma membrane
GO:0006198 IDA cAMP catabolic process
GO:0006626 ISS protein targeting to mitochondrion
GO:0007165 IEA signal transduction
GO:0007596 TAS blood coagulation
GO:0008144 IDA drug binding
GO:0008152 IEA:IDA metabolic process
GO:0019933 IMP cAMP-mediated signaling
GO:0019934 IMP cGMP-mediated signaling
GO:0030224 IEP monocyte differentiation
GO:0030424 IEA axon
GO:0030425 IEA dendrite
GO:0030552 IMP cAMP binding
GO:0030553 IMP cGMP binding
GO:0030818 ISS negative regulation of cAMP biosynthetic process
GO:0030823 IEA regulation of cGMP metabolic process
GO:0030911 IPI TPR domain binding
GO:0033159 IDA negative regulation of protein import into nucleus, translocation
GO:0035690 IEP cellular response to drug
GO:0036006 IDA cellular response to macrophage colony-stimulating factor stimulus
GO:0042734 ISS presynaptic membrane
GO:0042803 IPI protein homodimerization activity
GO:0043116 IMP negative regulation of vascular permeability
GO:0043117 IMP positive regulation of vascular permeability
GO:0046069 IDA cGMP catabolic process
GO:0046872 IEA metal ion binding
GO:0048471 IDA perinuclear region of cytoplasm
GO:0050729 ISS positive regulation of inflammatory response
GO:0061028 ISS establishment of endothelial barrier
GO:0070588 TAS calcium ion transmembrane transport
GO:0071260 ISS cellular response to mechanical stimulus
GO:0071321 IDA cellular response to cGMP
GO:0071560 IEP cellular response to transforming growth factor beta stimulus
GO:0097011 IDA cellular response to granulocyte macrophage colony-stimulating factor stimulus

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000079064 PDE2A (1 of 2) phosphodiesterase 2A, cGMP-stimulated protein_coding Danio_rerio
ENSDARG00000091508 PDE2A (2 of 2) phosphodiesterase 2A, cGMP-stimulated protein_coding Danio_rerio
ENSMUSG00000030653 Pde2a phosphodiesterase 2A, cGMP-stimulated protein_coding Mus_musculus

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