C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: phosphodiesterase 2A, cGMP-stimulated
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000540345 PDE2A-012 ENSG00000186642 9606 - 11:72577296-72669064 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; BladderBrainColonLiverLungENST00000540345
Transcript ID Bladder Brain Colon Liver Lung
ENST00000540345 1.403±0.00 11.246±0.00 0.936±0.00 2.768±0.00 0.416±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008XL CIL_0008XL_0001 VISTA 11:72069476-72670457

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000122 IDA negative regulation of transcription from RNA polymerase II promoter
GO:0004112 IDA cyclic-nucleotide phosphodiesterase activity
GO:0004114 IEA 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0004118 IDA cGMP-stimulated cyclic-nucleotide phosphodiesterase activity
GO:0005262 TAS calcium channel activity
GO:0005515 IPI:IEA protein binding
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005759 ISS mitochondrial matrix
GO:0005783 ISS endoplasmic reticulum
GO:0005794 ISS Golgi apparatus
GO:0005829 IDA cytosol
GO:0005886 IDA plasma membrane
GO:0006198 IDA cAMP catabolic process
GO:0006626 ISS protein targeting to mitochondrion
GO:0007165 IEA signal transduction
GO:0007596 TAS blood coagulation
GO:0008144 IDA drug binding
GO:0008152 IEA:IDA metabolic process
GO:0019933 IMP cAMP-mediated signaling
GO:0019934 IMP cGMP-mediated signaling
GO:0030224 IEP monocyte differentiation
GO:0030552 IMP cAMP binding
GO:0030553 IMP cGMP binding
GO:0030818 ISS negative regulation of cAMP biosynthetic process
GO:0030911 IPI TPR domain binding
GO:0033159 IDA negative regulation of protein import into nucleus, translocation
GO:0035690 IEP cellular response to drug
GO:0036006 IDA cellular response to macrophage colony-stimulating factor stimulus
GO:0042734 ISS presynaptic membrane
GO:0042803 IPI protein homodimerization activity
GO:0043116 IMP negative regulation of vascular permeability
GO:0043117 IMP positive regulation of vascular permeability
GO:0046069 IDA cGMP catabolic process
GO:0046872 IEA metal ion binding
GO:0048471 IDA perinuclear region of cytoplasm
GO:0050729 ISS positive regulation of inflammatory response
GO:0061028 ISS establishment of endothelial barrier
GO:0070588 TAS calcium ion transmembrane transport
GO:0071260 ISS cellular response to mechanical stimulus
GO:0071321 IDA cellular response to cGMP
GO:0071560 IEP cellular response to transforming growth factor beta stimulus
GO:0097011 IDA cellular response to granulocyte macrophage colony-stimulating factor stimulus

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000166652 Pde2a-203 protein_coding Mus_musculus 0 3358
ENSMUST00000084894 Pde2a-201 protein_coding Mus_musculus 0 3358
ENSMUST00000163751 Pde2a-202 protein_coding Mus_musculus 0 3314

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