C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: microtubule-associated protein tau
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000186868 MAPT 9606 + 17:45894382-46028334 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000262410 MAPT-201 45894382-46028334 protein_coding
  ENST00000334239 MAPT-001 45894668-46024183 protein_coding
  ENST00000340799 MAPT-202 45894382-46028334 protein_coding
  ENST00000344290 MAPT-203 45894382-46028334 protein_coding
  ENST00000351559 MAPT-204 45894382-46028334 protein_coding
  ENST00000415613 MAPT-004 45962338-46024171 protein_coding
  ENST00000420682 MAPT-003 45962338-46024171 protein_coding
  ENST00000431008 MAPT-006 45962338-46024171 protein_coding
  ENST00000446361 MAPT-002 45894674-46028334 protein_coding
  ENST00000535772 MAPT-205 45894382-46028334 protein_coding
  ENST00000570299 MAPT-013 45894576-46018730 processed_transcript
  ENST00000571311 MAPT-011 45894566-45978425 nonsense_mediated_decay
  ENST00000571987 MAPT-008 45962338-46024171 protein_coding
  ENST00000572440 MAPT-014 45975492-45980506 retained_intron
  ENST00000574436 MAPT-007 45962338-46024171 protein_coding
  ENST00000576238 MAPT-010 45982866-45983930 retained_intron
  ENST00000576518 MAPT-009 45972783-46024431 protein_coding
  ENST00000577017 MAPT-012 45985659-45987095 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000262410ENST00000334239ENST00000340799ENST00000420682ENST00000446361ENST00000535772ENST00000571311ENST00000572440ENST00000576518
Transcript ID Adipose Adrenal Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000262410 N/A N/A N/A N/A N/A 0.559±0.00 N/A N/A N/A 5.477±0.00 N/A N/A N/A
ENST00000334239 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 32.891±5.56
ENST00000340799 1.220±0.00 0.676±0.00 10.692±3.84 1.225±0.00 N/A 2.055±0.00 N/A N/A N/A 4.394±3.54 N/A 1.803±0.00 2.808±0.79
ENST00000420682 N/A N/A N/A 1.035±0.00 0.193±0.00 N/A N/A N/A N/A 2.846±0.00 N/A N/A N/A
ENST00000446361 N/A N/A 29.086±0.00 N/A N/A N/A 1.050±1.01 0.079±0.00 0.136±0.00 N/A 0.870±0.00 N/A N/A
ENST00000535772 N/A 0.412±0.00 32.191±0.00 1.239±0.00 0.962±0.00 N/A N/A N/A N/A N/A 0.110±0.05 0.641±0.00 N/A
ENST00000571311 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.393±0.00 N/A N/A
ENST00000572440 N/A N/A N/A N/A N/A 0.189±0.00 N/A N/A N/A 0.734±0.00 0.009±0.00 N/A N/A
ENST00000576518 N/A N/A N/A N/A N/A N/A 0.009±0.00 N/A N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0004WG CIL_0004WG_0001 CGP 17:45844835-46028334

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000226 IDA microtubule cytoskeleton organization
GO:0001764 IEA neuron migration
GO:0005200 TAS structural constituent of cytoskeleton
GO:0005515 IPI protein binding
GO:0005634 IEA nucleus
GO:0005737 IEA cytoplasm
GO:0005829 TAS cytosol
GO:0005874 IEA microtubule
GO:0005875 TAS microtubule associated complex
GO:0005886 IDA plasma membrane
GO:0005930 IEA axoneme
GO:0006915 TAS apoptotic process
GO:0006921 TAS cellular component disassembly involved in execution phase of apoptosis
GO:0007409 IEA axonogenesis
GO:0007628 IEA adult walking behavior
GO:0008017 IDA microtubule binding
GO:0008088 IEA axon cargo transport
GO:0010506 IGI regulation of autophagy
GO:0015630 IEA microtubule cytoskeleton
GO:0015631 IEA tubulin binding
GO:0017124 IPI SH3 domain binding
GO:0019899 IPI enzyme binding
GO:0019901 IEA protein kinase binding
GO:0030424 IDA axon
GO:0030426 IDA growth cone
GO:0031113 NAS regulation of microtubule polymerization
GO:0031116 IDA positive regulation of microtubule polymerization
GO:0032387 IEA negative regulation of intracellular transport
GO:0034185 IPI apolipoprotein binding
GO:0034399 IDA nuclear periphery
GO:0036464 IDA cytoplasmic ribonucleoprotein granule
GO:0045298 IDA tubulin complex
GO:0045773 IDA positive regulation of axon extension
GO:0047497 IEA mitochondrion transport along microtubule
GO:0048675 IEA axon extension
GO:0048699 NAS generation of neurons
GO:0060632 IEA regulation of microtubule-based movement
GO:0071813 IPI lipoprotein particle binding

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000087616 maptb microtubule-associated protein tau b protein_coding Danio_rerio
ENSDARG00000089314 mapta microtubule-associated protein tau a protein_coding Danio_rerio
ENSMUSG00000018411 Mapt microtubule-associated protein tau protein_coding Mus_musculus

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