C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: megakaryoblastic leukemia (translocation) 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000196588 MKL1 9606 - 22:40410281-40636702 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000355630 MKL1-001 40410281-40636685 protein_coding
  ENST00000396617 MKL1-201 40410282-40636685 protein_coding
  ENST00000402042 MKL1-002 40410290-40636691 protein_coding
  ENST00000402630 MKL1-009 40429351-40463418 protein_coding
  ENST00000407029 MKL1-003 40410302-40463434 protein_coding
  ENST00000422851 MKL1-006 40431405-40533811 protein_coding
  ENST00000463769 MKL1-004 40463228-40636687 processed_transcript
  ENST00000466278 MKL1-005 40519585-40636702 processed_transcript
  ENST00000477468 MKL1-008 40411839-40417734 retained_intron
  ENST00000614754 MKL1-202 40410282-40436310 protein_coding
  ENST00000618196 MKL1-203 40410288-40533880 protein_coding
  ENST00000618417 MKL1-204 40411144-40552311 protein_coding
  ENST00000620651 MKL1-205 40410282-40436310 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungOvaryPlacentaTestisENST00000355630ENST00000614754ENST00000620651
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Ovary Placenta Testis
ENST00000355630 12.760±0.00 9.067±0.00 1.169±0.00 13.537±0.00 5.353±2.85 6.634±0.00 4.265±0.00 8.670±0.00 3.375±0.65 4.374±2.22 17.589±3.42 12.429±1.11 18.335±0.09
ENST00000614754 N/A N/A N/A N/A N/A N/A N/A N/A N/A 9.932±0.00 N/A N/A N/A
ENST00000620651 N/A 10.016±0.00 N/A N/A 7.440±0.00 N/A N/A N/A N/A 7.575±0.00 N/A N/A 17.426±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0005W1 CIL_0005W1_0001 CGP 22:40370591-40636702
CIL_0005W2 CIL_0005W2_0001 CGP 22:40410281-40682814

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000976 IEA transcription regulatory region sequence-specific DNA binding
GO:0003676 IEA nucleic acid binding
GO:0003700 IEA sequence-specific DNA binding transcription factor activity
GO:0003713 ISS transcription coactivator activity
GO:0003779 IDA actin binding
GO:0003785 ISS actin monomer binding
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0006351 IEA transcription, DNA-templated
GO:0006357 IEA regulation of transcription from RNA polymerase II promoter
GO:0010735 IDA positive regulation of transcription via serum response element binding
GO:0043154 IEA negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043522 IPI leucine zipper domain binding
GO:0045893 IEA positive regulation of transcription, DNA-templated
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0051145 IMP smooth muscle cell differentiation
GO:2001234 IEA negative regulation of apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000075867 mkl1a megakaryoblastic leukemia (translocation) 1a protein_coding Danio_rerio
ENSDARG00000076229 mkl1b megakaryoblastic leukemia (translocation) 1b protein_coding Danio_rerio
ENSMUSG00000042292 Mkl1 MKL (megakaryoblastic leukemia)/myocardin-like 1 protein_coding Mus_musculus

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