C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: MKL (megakaryoblastic leukemia)/myocardin-like 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000042292 Mkl1 10090 - 15:81012281-81190757 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000109579 Mkl1-002 81012291-81105083 protein_coding
  ENSMUST00000123243 Mkl1-007 81026419-81190728 retained_intron
  ENSMUST00000131235 Mkl1-005 81012291-81190723 protein_coding
  ENSMUST00000134469 Mkl1-004 81012281-81190733 protein_coding
  ENSMUST00000135047 Mkl1-003 81015854-81045546 protein_coding
  ENSMUST00000138769 Mkl1-010 81016763-81018188 retained_intron
  ENSMUST00000145779 Mkl1-009 81020238-81021302 retained_intron
  ENSMUST00000147921 Mkl1-006 81045133-81190522 retained_intron
  ENSMUST00000149582 Mkl1-001 81012281-81190757 protein_coding
  ENSMUST00000154797 Mkl1-008 81022489-81023970 retained_intron

Mus musculus EnsemblGRCm38

Genome
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Genes
Gene structures from Ensembl
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Transcripts
Structures from Ensembl
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Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000109579ENSMUST00000134469ENSMUST00000149582
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000109579 N/A N/A 3.631±0.00 10.570±0.00 4.646±2.68 N/A 0.949±0.00 1.492±0.30 N/A 4.290±0.00 1.533±0.00 3.124±1.01 4.854±2.10 N/A
ENSMUST00000134469 N/A 8.088±1.01 N/A N/A N/A N/A N/A 1.370±0.00 0.887±0.00 N/A N/A 4.804±1.29 N/A N/A
ENSMUST00000149582 4.657±1.07 4.816±3.04 5.641±0.97 11.433±4.63 6.804±2.97 14.194±4.59 1.289±0.12 3.072±0.98 1.511±0.64 7.572±0.72 2.994±1.79 7.653±2.31 4.610±2.30 9.652±3.17

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0005W1 CIL_0005W1_0002 CGP 15:80977765-81190757
CIL_0005W2 CIL_0005W2_0002 CGP 15:81012281-81238963

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000976 IDA transcription regulatory region sequence-specific DNA binding
GO:0003700 IDA sequence-specific DNA binding transcription factor activity
GO:0003713 IDA transcription coactivator activity
GO:0003779 IDA actin binding
GO:0003785 IDA actin monomer binding
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0006351 IEA transcription, DNA-templated
GO:0006357 IEA regulation of transcription from RNA polymerase II promoter
GO:0010735 ISS positive regulation of transcription via serum response element binding
GO:0043154 IDA negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043522 IEA leucine zipper domain binding
GO:0045893 IDA positive regulation of transcription, DNA-templated
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0051145 IEA smooth muscle cell differentiation
GO:2001234 IDA negative regulation of apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000075867 mkl1a megakaryoblastic leukemia (translocation) 1a protein_coding Danio_rerio
ENSDARG00000076229 mkl1b megakaryoblastic leukemia (translocation) 1b protein_coding Danio_rerio
ENSG00000196588 MKL1 megakaryoblastic leukemia (translocation) 1 protein_coding Homo_sapiens

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