C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: adenosine deaminase
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000196839 ADA 9606 - 20:44619522-44652233 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000372874 ADA-001 44619522-44651742 protein_coding
  ENST00000464097 ADA-002 44619522-44626491 processed_transcript
  ENST00000492931 ADA-003 44619810-44651691 processed_transcript
  ENST00000535573 ADA-005 44636071-44652233 processed_transcript
  ENST00000536076 ADA-006 44626517-44652114 processed_transcript
  ENST00000536532 ADA-004 44619579-44651681 nonsense_mediated_decay
  ENST00000537820 ADA-008 44619810-44651691 protein_coding
  ENST00000539235 ADA-007 44619810-44651691 nonsense_mediated_decay
  ENST00000545776 ADA-009 44626323-44651661 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; LiverOvaryENST00000372874ENST00000536532ENST00000537820ENST00000545776
Transcript ID Liver Ovary
ENST00000372874 2.244±0.00 6.700±1.30
ENST00000536532 N/A 0.593±0.00
ENST00000537820 N/A 0.830±0.00
ENST00000545776 N/A 18.116±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007R9 CIL_0007R9_0001 VISTA 20:44272530-44874028
CIL_0003UY CIL_0003UY_0001 CGP 20:44496221-44624247
CIL_0006IR CIL_0006IR_0002 CGP 20:44531785-44652233
CIL_0006IS CIL_0006IS_0002 CGP 20:44619522-44728509

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001666 IDA response to hypoxia
GO:0001701 IEA in utero embryonic development
GO:0001821 IEA histamine secretion
GO:0001829 IEA trophectodermal cell differentiation
GO:0001883 IEA purine nucleoside binding
GO:0001889 IEA liver development
GO:0001890 IEA placenta development
GO:0002314 IEA germinal center B cell differentiation
GO:0002636 IEA positive regulation of germinal center formation
GO:0002686 IEA negative regulation of leukocyte migration
GO:0002906 IEA negative regulation of mature B cell apoptotic process
GO:0004000 ISS adenosine deaminase activity
GO:0005515 IPI protein binding
GO:0005615 IEA extracellular space
GO:0005737 IDA cytoplasm
GO:0005764 IDA lysosome
GO:0005829 TAS cytosol
GO:0005886 IDA plasma membrane
GO:0006144 TAS purine nucleobase metabolic process
GO:0006154 ISS adenosine catabolic process
GO:0006157 IEA deoxyadenosine catabolic process
GO:0007155 IEA cell adhesion
GO:0007568 IEA aging
GO:0008152 IEA metabolic process
GO:0008270 ISS zinc ion binding
GO:0009168 IEA purine ribonucleoside monophosphate biosynthetic process
GO:0009897 IDA external side of plasma membrane
GO:0009986 IDA cell surface
GO:0010460 IEA positive regulation of heart rate
GO:0016020 IDA membrane
GO:0019239 IEA deaminase activity
GO:0030054 IEA cell junction
GO:0030324 IEA lung development
GO:0030890 IEA positive regulation of B cell proliferation
GO:0031410 IEA cytoplasmic vesicle
GO:0032261 IMP purine nucleotide salvage
GO:0032839 IEA dendrite cytoplasm
GO:0033089 IEA positive regulation of T cell differentiation in thymus
GO:0033197 IEA response to vitamin E
GO:0033632 IDA regulation of cell-cell adhesion mediated by integrin
GO:0042110 IDA T cell activation
GO:0042323 IEA negative regulation of circadian sleep/wake cycle, non-REM sleep
GO:0042493 IEA response to drug
GO:0042542 IEA response to hydrogen peroxide
GO:0043025 IEA neuronal cell body
GO:0043066 IEA negative regulation of apoptotic process
GO:0043101 TAS purine-containing compound salvage
GO:0043103 IBA hypoxanthine salvage
GO:0043278 IEA response to morphine
GO:0044281 TAS small molecule metabolic process
GO:0045187 IEA regulation of circadian sleep/wake cycle, sleep
GO:0045580 IEA regulation of T cell differentiation
GO:0045582 IEA positive regulation of T cell differentiation
GO:0045987 IEA positive regulation of smooth muscle contraction
GO:0046061 IEA dATP catabolic process
GO:0046101 IEA hypoxanthine biosynthetic process
GO:0046103 ISS inosine biosynthetic process
GO:0046111 IEA xanthine biosynthetic process
GO:0046638 IEA positive regulation of alpha-beta T cell differentiation
GO:0048286 IEA lung alveolus development
GO:0048541 IEA Peyer's patch development
GO:0048566 IEA embryonic digestive tract development
GO:0050728 IEA negative regulation of inflammatory response
GO:0050850 IEA positive regulation of calcium-mediated signaling
GO:0050862 IEA positive regulation of T cell receptor signaling pathway
GO:0050870 IEA positive regulation of T cell activation
GO:0055086 TAS nucleobase-containing small molecule metabolic process
GO:0060169 IDA negative regulation of adenosine receptor signaling pathway
GO:0060407 IEA negative regulation of penile erection
GO:0070244 IEA negative regulation of thymocyte apoptotic process
GO:0070256 IEA negative regulation of mucus secretion

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000003113 ada adenosine deaminase protein_coding Danio_rerio
ENSMUSG00000017697 Ada adenosine deaminase protein_coding Mus_musculus

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