C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: SRC proto-oncogene, non-receptor tyrosine kinase
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000197122 SRC 9606 + 20:37344685-37406050 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000358208 SRC-201 37382604-37405432 protein_coding
  ENST00000373558 SRC-005 37384150-37406050 protein_coding
  ENST00000373567 SRC-002 37383668-37406050 protein_coding
  ENST00000373578 SRC-001 37346154-37406050 protein_coding
  ENST00000467556 SRC-007 37400149-37401957 retained_intron
  ENST00000472968 SRC-003 37384323-37394174 processed_transcript
  ENST00000477066 SRC-004 37396426-37405422 processed_transcript
  ENST00000477475 SRC-010 37400251-37402292 processed_transcript
  ENST00000489153 SRC-006 37393745-37397746 processed_transcript
  ENST00000493775 SRC-009 37402313-37403031 processed_transcript
  ENST00000497734 SRC-008 37344685-37382787 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000358208ENST00000373578ENST00000477066ENST00000489153ENST00000497734
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000358208 3.911±0.00 5.286±0.00 0.899±0.00 3.690±2.99 3.537±1.22 11.283±0.00 1.376±0.00 13.404±0.00 2.624±1.19 5.869±5.16 0.531±0.17 13.553±11.49 7.615±2.88 11.776±3.10
ENST00000373578 N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.898±0.00 N/A 1.523±0.90 1.967±0.00 4.027±0.00
ENST00000477066 1.319±0.00 3.179±0.00 N/A N/A 0.831±0.00 4.072±1.83 0.189±0.00 0.473±0.00 N/A N/A N/A 7.021±6.03 3.399±0.00 10.366±1.70
ENST00000489153 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 2.071±0.00 N/A N/A N/A
ENST00000497734 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 23.464±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0006YE CIL_0006YE_0001 CGP 20:37289638-37406050
CIL_0006Y4 CIL_0006Y4_0001 CGP 20:37344685-37527931

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004672 IDA:IEA protein kinase activity
GO:0004713 IDA:IEA protein tyrosine kinase activity
GO:0004715 TAS non-membrane spanning protein tyrosine kinase activity
GO:0005070 TAS SH3/SH2 adaptor activity
GO:0005080 IEA protein kinase C binding
GO:0005102 IPI receptor binding
GO:0005158 IEA insulin receptor binding
GO:0005178 TAS integrin binding
GO:0005515 IPI:IEA protein binding
GO:0005524 IEA ATP binding
GO:0005634 IEA nucleus
GO:0005737 IDA cytoplasm
GO:0005739 IDA mitochondrion
GO:0005743 IDA mitochondrial inner membrane
GO:0005764 IDA lysosome
GO:0005770 IDA late endosome
GO:0005829 IDA cytosol
GO:0005856 IEA cytoskeleton
GO:0005884 IEA actin filament
GO:0005886 IDA plasma membrane
GO:0005901 IDA caveola
GO:0006468 IEA protein phosphorylation
GO:0007049 IEA cell cycle
GO:0007155 IEA cell adhesion
GO:0007165 TAS signal transduction
GO:0007172 TAS signal complex assembly
GO:0007173 TAS epidermal growth factor receptor signaling pathway
GO:0007179 IMP transforming growth factor beta receptor signaling pathway
GO:0007229 IMP integrin-mediated signaling pathway
GO:0007265 TAS Ras protein signal transduction
GO:0007411 TAS axon guidance
GO:0007596 TAS blood coagulation
GO:0008022 IEA protein C-terminus binding
GO:0008283 IEA cell proliferation
GO:0008543 TAS fibroblast growth factor receptor signaling pathway
GO:0009612 IEA response to mechanical stimulus
GO:0009615 IEA response to virus
GO:0010447 IEA response to acidity
GO:0010628 IEA positive regulation of gene expression
GO:0010632 IMP regulation of epithelial cell migration
GO:0010641 IEA positive regulation of platelet-derived growth factor receptor signaling pathway
GO:0010907 IEA positive regulation of glucose metabolic process
GO:0014069 IEA postsynaptic density
GO:0014911 IEA positive regulation of smooth muscle cell migration
GO:0016032 IEA viral process
GO:0016301 TAS kinase activity
GO:0016337 IEA single organismal cell-cell adhesion
GO:0016477 IEA cell migration
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0018105 IEA peptidyl-serine phosphorylation
GO:0018108 IDA peptidyl-tyrosine phosphorylation
GO:0019899 IPI enzyme binding
GO:0019901 IEA protein kinase binding
GO:0019904 IEA protein domain specific binding
GO:0020037 IDA heme binding
GO:0022407 IMP regulation of cell-cell adhesion
GO:0030168 TAS platelet activation
GO:0030331 IEA estrogen receptor binding
GO:0030900 IEA forebrain development
GO:0031295 TAS T cell costimulation
GO:0031667 IEA response to nutrient levels
GO:0031954 IEA positive regulation of protein autophosphorylation
GO:0032148 IEA activation of protein kinase B activity
GO:0032403 IEA protein complex binding
GO:0032463 IMP negative regulation of protein homooligomerization
GO:0032587 IEA ruffle membrane
GO:0032869 IEA cellular response to insulin stimulus
GO:0033146 IEA regulation of intracellular estrogen receptor signaling pathway
GO:0033625 TAS positive regulation of integrin activation
GO:0034332 IEA adherens junction organization
GO:0034446 IEA substrate adhesion-dependent cell spreading
GO:0035556 IDA intracellular signal transduction
GO:0036035 IEA osteoclast development
GO:0036120 IEA cellular response to platelet-derived growth factor stimulus
GO:0038096 TAS Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0042169 IPI SH2 domain binding
GO:0042493 IEA response to drug
GO:0042542 IEA response to hydrogen peroxide
GO:0043005 IEA neuron projection
GO:0043065 IEA positive regulation of apoptotic process
GO:0043066 IMP negative regulation of apoptotic process
GO:0043114 TAS regulation of vascular permeability
GO:0043149 IMP stress fiber assembly
GO:0043154 IMP negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043393 IEA regulation of protein binding
GO:0043406 IEA positive regulation of MAP kinase activity
GO:0043552 IEA positive regulation of phosphatidylinositol 3-kinase activity
GO:0044325 IPI ion channel binding
GO:0045056 IEA transcytosis
GO:0045087 TAS innate immune response
GO:0045124 TAS regulation of bone resorption
GO:0045453 ISS bone resorption
GO:0045737 IEA positive regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045785 IEA positive regulation of cell adhesion
GO:0045892 IEA negative regulation of transcription, DNA-templated
GO:0045893 IEA positive regulation of transcription, DNA-templated
GO:0046628 IEA positive regulation of insulin receptor signaling pathway
GO:0046777 IDA protein autophosphorylation
GO:0046875 IPI ephrin receptor binding
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0048471 IEA perinuclear region of cytoplasm
GO:0048477 IEA oogenesis
GO:0050715 IEA positive regulation of cytokine secretion
GO:0050839 IEA cell adhesion molecule binding
GO:0050847 ISS progesterone receptor signaling pathway
GO:0050900 TAS leukocyte migration
GO:0051219 IPI phosphoprotein binding
GO:0051222 IEA positive regulation of protein transport
GO:0051385 IEA response to mineralocorticoid
GO:0051602 IEA response to electrical stimulus
GO:0051895 ISS negative regulation of focal adhesion assembly
GO:0051897 IMP positive regulation of protein kinase B signaling
GO:0051902 IMP negative regulation of mitochondrial depolarization
GO:0060065 IEA uterus development
GO:0060444 IEA branching involved in mammary gland duct morphogenesis
GO:0060491 IEA regulation of cell projection assembly
GO:0061024 TAS membrane organization
GO:0070062 IDA extracellular vesicular exosome
GO:0070374 IEA positive regulation of ERK1 and ERK2 cascade
GO:0070542 IEA response to fatty acid
GO:0070555 IMP response to interleukin-1
GO:0070851 IPI growth factor receptor binding
GO:0071222 IEA cellular response to lipopolysaccharide
GO:0071393 ISS cellular response to progesterone stimulus
GO:0071398 IEA cellular response to fatty acid
GO:0071456 IEA cellular response to hypoxia
GO:0071803 IEA positive regulation of podosome assembly
GO:0090263 IEA positive regulation of canonical Wnt signaling pathway
GO:1902533 IEA positive regulation of intracellular signal transduction
GO:2000573 IEA positive regulation of DNA biosynthetic process
GO:2000641 IMP regulation of early endosome to late endosome transport
GO:2000811 IMP negative regulation of anoikis
GO:2001237 IMP negative regulation of extrinsic apoptotic signaling pathway
GO:2001243 IMP negative regulation of intrinsic apoptotic signaling pathway
GO:2001286 IMP regulation of caveolin-mediated endocytosis

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000008107 src v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) protein_coding Danio_rerio
ENSMUSG00000027646 Src Rous sarcoma oncogene protein_coding Mus_musculus

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