C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: Rous sarcoma oncogene
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000027646 Src 10090 + 2:157418444-157471862 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000029175 Src-001 157424280-157471862 protein_coding
  ENSMUST00000092576 Src-201 157424293-157471838 protein_coding
  ENSMUST00000109529 Src-006 157457085-157470355 protein_coding
  ENSMUST00000109531 Src-005 157455671-157471838 protein_coding
  ENSMUST00000109533 Src-007 157418444-157471835 protein_coding
  ENSMUST00000129770 Src-002 157424392-157458600 processed_transcript
  ENSMUST00000133900 Src-003 157424392-157455606 processed_transcript
  ENSMUST00000145715 Src-004 157424116-157455707 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000029175ENSMUST00000092576ENSMUST00000109529ENSMUST00000109531ENSMUST00000109533
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000029175 12.355±4.81 6.289±3.30 25.456±2.63 7.368±2.60 10.073±1.33 55.984±5.69 1.497±0.55 12.324±0.91 1.342±0.55 23.981±3.48 N/A 27.228±4.23 24.001±15.04 1.618±0.72
ENSMUST00000092576 N/A 2.000±0.00 N/A 22.861±13.80 2.603±0.29 9.228±0.00 0.256±0.00 N/A 0.936±0.25 N/A 0.509±0.00 N/A N/A 0.770±0.30
ENSMUST00000109529 N/A N/A N/A 18.167±0.00 N/A N/A N/A N/A N/A N/A 0.310±0.00 N/A N/A N/A
ENSMUST00000109531 N/A 1.757±0.37 7.705±2.30 11.673±0.00 3.935±0.00 N/A 0.721±0.46 N/A 0.564±0.23 N/A 0.566±0.25 7.060±2.19 11.926±6.63 0.961±0.00
ENSMUST00000109533 N/A 3.900±0.77 N/A N/A 2.295±0.74 N/A N/A N/A 0.877±0.38 N/A 0.361±0.16 5.611±0.00 31.550±3.11 N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0006YE CIL_0006YE_0002 CGP 2:157367594-157471862
CIL_0006Y4 CIL_0006Y4_0002 CGP 2:157418444-157571274

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004672 IDA protein kinase activity
GO:0004713 IMP protein tyrosine kinase activity
GO:0004715 IEA non-membrane spanning protein tyrosine kinase activity
GO:0005080 IEA protein kinase C binding
GO:0005102 IEA receptor binding
GO:0005158 IEA insulin receptor binding
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005634 IEA nucleus
GO:0005737 IEA cytoplasm
GO:0005739 IEA mitochondrion
GO:0005743 IEA mitochondrial inner membrane
GO:0005764 IEA lysosome
GO:0005770 IEA late endosome
GO:0005829 TAS cytosol
GO:0005884 IDA actin filament
GO:0005886 IDA plasma membrane
GO:0005901 IEA caveola
GO:0006468 IDA protein phosphorylation
GO:0007049 IEA cell cycle
GO:0007173 IEA epidermal growth factor receptor signaling pathway
GO:0007179 IEA transforming growth factor beta receptor signaling pathway
GO:0007229 IEA integrin-mediated signaling pathway
GO:0008022 IEA protein C-terminus binding
GO:0008283 IEA cell proliferation
GO:0009612 IEA response to mechanical stimulus
GO:0009615 IEA response to virus
GO:0010447 IEA response to acidity
GO:0010628 IEA positive regulation of gene expression
GO:0010632 IEA regulation of epithelial cell migration
GO:0010641 IEA positive regulation of platelet-derived growth factor receptor signaling pathway
GO:0010907 IEA positive regulation of glucose metabolic process
GO:0014069 IEA postsynaptic density
GO:0014911 IEA positive regulation of smooth muscle cell migration
GO:0016301 IMP kinase activity
GO:0016337 IEA single organismal cell-cell adhesion
GO:0016477 IMP cell migration
GO:0018105 IEA peptidyl-serine phosphorylation
GO:0018108 IDA peptidyl-tyrosine phosphorylation
GO:0019899 IEA enzyme binding
GO:0019901 IEA protein kinase binding
GO:0019904 IPI protein domain specific binding
GO:0020037 ISS heme binding
GO:0022407 IEA regulation of cell-cell adhesion
GO:0030331 IEA estrogen receptor binding
GO:0030900 IGI forebrain development
GO:0031667 IEA response to nutrient levels
GO:0031954 IEA positive regulation of protein autophosphorylation
GO:0032148 IEA activation of protein kinase B activity
GO:0032403 IEA protein complex binding
GO:0032463 IEA negative regulation of protein homooligomerization
GO:0032587 IDA ruffle membrane
GO:0032869 IEA cellular response to insulin stimulus
GO:0033146 IMP regulation of intracellular estrogen receptor signaling pathway
GO:0034332 IEA adherens junction organization
GO:0034446 IDA substrate adhesion-dependent cell spreading
GO:0035556 IGI intracellular signal transduction
GO:0036035 IGI osteoclast development
GO:0036120 IDA cellular response to platelet-derived growth factor stimulus
GO:0042169 IEA SH2 domain binding
GO:0042493 IEA response to drug
GO:0042542 IEA response to hydrogen peroxide
GO:0043005 IEA neuron projection
GO:0043065 IEA positive regulation of apoptotic process
GO:0043066 IEA negative regulation of apoptotic process
GO:0043149 IEA stress fiber assembly
GO:0043154 IEA negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043393 IDA regulation of protein binding
GO:0043406 IEA positive regulation of MAP kinase activity
GO:0043552 IEA positive regulation of phosphatidylinositol 3-kinase activity
GO:0044325 IEA ion channel binding
GO:0045056 IEA transcytosis
GO:0045453 IMP bone resorption
GO:0045737 IEA positive regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045785 IEA positive regulation of cell adhesion
GO:0045892 IEA negative regulation of transcription, DNA-templated
GO:0045893 IEA positive regulation of transcription, DNA-templated
GO:0046628 IEA positive regulation of insulin receptor signaling pathway
GO:0046777 IEA protein autophosphorylation
GO:0046875 IPI ephrin receptor binding
GO:0048011 IEA neurotrophin TRK receptor signaling pathway
GO:0048471 IDA perinuclear region of cytoplasm
GO:0048477 IMP oogenesis
GO:0050715 IEA positive regulation of cytokine secretion
GO:0050839 IEA cell adhesion molecule binding
GO:0050847 IEA progesterone receptor signaling pathway
GO:0051219 IEA phosphoprotein binding
GO:0051222 IEA positive regulation of protein transport
GO:0051385 IEA response to mineralocorticoid
GO:0051602 IEA response to electrical stimulus
GO:0051895 IEA negative regulation of focal adhesion assembly
GO:0051897 IEA positive regulation of protein kinase B signaling
GO:0051902 IEA negative regulation of mitochondrial depolarization
GO:0060065 IMP uterus development
GO:0060444 IMP branching involved in mammary gland duct morphogenesis
GO:0060491 IGI regulation of cell projection assembly
GO:0070062 IEA extracellular vesicular exosome
GO:0070374 IMP positive regulation of ERK1 and ERK2 cascade
GO:0070542 IEA response to fatty acid
GO:0070555 IEA response to interleukin-1
GO:0070851 IEA growth factor receptor binding
GO:0071222 IEA cellular response to lipopolysaccharide
GO:0071393 IEA cellular response to progesterone stimulus
GO:0071398 IEA cellular response to fatty acid
GO:0071456 IEA cellular response to hypoxia
GO:0071803 IDA positive regulation of podosome assembly
GO:0090263 IGI positive regulation of canonical Wnt signaling pathway
GO:1902533 IEA positive regulation of intracellular signal transduction
GO:2000573 IEA positive regulation of DNA biosynthetic process
GO:2000641 IEA regulation of early endosome to late endosome transport
GO:2000811 IEA negative regulation of anoikis
GO:2001237 IEA negative regulation of extrinsic apoptotic signaling pathway
GO:2001243 IEA negative regulation of intrinsic apoptotic signaling pathway
GO:2001286 IEA regulation of caveolin-mediated endocytosis

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000008107 src v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) protein_coding Danio_rerio
ENSG00000197122 SRC SRC proto-oncogene, non-receptor tyrosine kinase protein_coding Homo_sapiens

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