C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000197579 TOPORS 9606 - 9:32540544-32552553 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000360538 TOPORS-001 32540544-32552553 protein_coding
  ENST00000379858 TOPORS-002 32540826-32552553 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000360538ENST00000379858
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000360538 1.885±0.00 2.242±0.00 N/A 1.789±0.09 2.141±0.19 N/A 0.419±0.00 2.488±0.00 1.891±0.97 2.713±0.21 0.472±0.32 3.033±1.12 1.549±0.34 5.202±0.00
ENST00000379858 2.578±0.00 1.847±0.00 3.524±0.00 3.457±0.00 3.103±0.96 3.537±0.56 1.033±0.00 3.941±0.48 1.749±0.77 2.368±0.78 1.270±0.86 3.546±1.51 4.139±3.05 7.403±2.74

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00065D CIL_00065D_0001 CGP 9:32455705-32552553
CIL_00061N CIL_00061N_0001 CGP 9:32540544-32573184

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000151 IDA ubiquitin ligase complex
GO:0000922 IDA spindle pole
GO:0000930 IDA gamma-tubulin complex
GO:0003677 IDA DNA binding
GO:0003823 IPI antigen binding
GO:0004842 IDA ubiquitin-protein transferase activity
GO:0005515 IPI:IEA protein binding
GO:0005634 IDA nucleus
GO:0005814 IDA centriole
GO:0005868 TAS cytoplasmic dynein complex
GO:0006351 NAS transcription, DNA-templated
GO:0006511 IMP ubiquitin-dependent protein catabolic process
GO:0006513 IDA protein monoubiquitination
GO:0006974 IDA cellular response to DNA damage stimulus
GO:0008270 IEA zinc ion binding
GO:0008630 IDA intrinsic apoptotic signaling pathway in response to DNA damage
GO:0010842 ISS retina layer formation
GO:0016605 IDA PML body
GO:0016607 IDA nuclear speck
GO:0016925 IDA protein sumoylation
GO:0019789 IDA SUMO ligase activity
GO:0030496 TAS midbody
GO:0032391 IDA photoreceptor connecting cilium
GO:0034504 IMP protein localization to nucleus
GO:0035845 ISS photoreceptor cell outer segment organization
GO:0036064 IDA ciliary basal body
GO:0042127 IEA regulation of cell proliferation
GO:0042771 IEA intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0043066 ISS negative regulation of apoptotic process
GO:0043161 IMP proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0044547 IPI DNA topoisomerase binding
GO:0045893 IEA positive regulation of transcription, DNA-templated
GO:0046548 ISS retinal rod cell development
GO:0046549 ISS retinal cone cell development
GO:0046872 IEA metal ion binding
GO:0051443 IDA positive regulation of ubiquitin-protein transferase activity
GO:0051457 IDA maintenance of protein location in nucleus
GO:0070936 IDA protein K48-linked ubiquitination

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000037260 toporsa topoisomerase I binding, arginine/serine-rich a protein_coding Danio_rerio
ENSDARG00000039784 toporsb topoisomerase I binding, arginine/serine-rich b protein_coding Danio_rerio
ENSMUSG00000036822 Topors topoisomerase I binding, arginine/serine-rich protein_coding Mus_musculus

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