C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: WW domain containing E3 ubiquitin protein ligase 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000198373 WWP2 9606 + 16:69762306-69941741 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000356003 WWP2-201 69838737-69941741 protein_coding
  ENST00000359154 WWP2-001 69762306-69941741 protein_coding
  ENST00000544162 WWP2-002 69798865-69940178 processed_transcript
  ENST00000561780 WWP2-004 69762328-69799276 protein_coding
  ENST00000563618 WWP2-009 69838737-69888158 processed_transcript
  ENST00000563659 WWP2-006 69762362-69798796 protein_coding
  ENST00000566463 WWP2-014 69917583-69940176 retained_intron
  ENST00000567161 WWP2-018 69934051-69936796 retained_intron
  ENST00000567303 WWP2-019 69936920-69939397 retained_intron
  ENST00000567579 WWP2-013 69894962-69929466 processed_transcript
  ENST00000567986 WWP2-008 69799046-69871865 retained_intron
  ENST00000568185 WWP2-016 69925012-69926096 processed_transcript
  ENST00000568684 WWP2-015 69924990-69941738 protein_coding
  ENST00000568818 WWP2-017 69930166-69933981 retained_intron
  ENST00000568845 WWP2-003 69762332-69788202 processed_transcript
  ENST00000569174 WWP2-012 69776187-69910250 protein_coding
  ENST00000569297 WWP2-011 69890798-69940621 processed_transcript
  ENST00000569620 WWP2-005 69762328-69840144 nonsense_mediated_decay
  ENST00000569658 WWP2-007 69762362-69799493 retained_intron
  ENST00000570104 WWP2-010 69871713-69908882 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000356003ENST00000359154ENST00000544162ENST00000566463ENST00000567303ENST00000568684ENST00000569174ENST00000569297ENST00000569658
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000356003 N/A N/A N/A N/A N/A N/A 0.585±0.00 N/A N/A N/A N/A N/A 4.680±2.04 N/A
ENST00000359154 4.642±0.00 6.433±0.00 N/A 5.164±4.22 4.950±3.62 2.593±1.81 1.594±1.14 3.607±3.17 2.337±1.62 3.722±1.83 5.520±0.00 6.346±4.25 6.634±3.20 7.523±0.98
ENST00000544162 N/A N/A N/A 1.575±0.00 1.172±0.00 1.153±0.00 0.605±0.00 N/A N/A N/A N/A 2.300±0.36 N/A 5.430±0.00
ENST00000566463 N/A N/A 2.535±0.00 N/A N/A N/A N/A 2.330±0.00 N/A N/A N/A N/A N/A N/A
ENST00000567303 N/A N/A N/A 3.598±0.00 5.244±0.00 N/A N/A N/A 4.454±0.00 N/A N/A 10.324±0.00 N/A 15.042±0.00
ENST00000568684 N/A N/A N/A N/A 2.541±0.00 N/A N/A 2.690±0.00 0.805±0.00 N/A N/A 1.747±0.00 N/A N/A
ENST00000569174 N/A 3.282±0.00 N/A 3.362±0.00 1.808±0.23 2.156±0.00 0.527±0.15 N/A N/A 2.824±0.00 N/A 2.621±0.00 1.845±0.00 N/A
ENST00000569297 N/A N/A N/A N/A N/A 3.274±0.00 N/A N/A N/A N/A N/A 1.711±0.85 7.496±0.00 5.125±0.00
ENST00000569658 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 2.167±0.00 N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008KB CIL_0008KB_0001 VISTA 16:69347064-69947578
CIL_0001NB CIL_0001NB_0001 CGP 16:69741867-69941741

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 ISS negative regulation of transcription from RNA polymerase II promoter
GO:0000151 TAS ubiquitin ligase complex
GO:0001085 ISS RNA polymerase II transcription factor binding
GO:0004842 IMP:IEA ubiquitin-protein transferase activity
GO:0005515 IPI:IEA protein binding
GO:0005634 IDA nucleus
GO:0005737 IBA cytoplasm
GO:0006464 TAS cellular protein modification process
GO:0008134 IPI transcription factor binding
GO:0010629 IMP negative regulation of gene expression
GO:0016020 IDA membrane
GO:0016567 IDA protein ubiquitination
GO:0016874 IEA ligase activity
GO:0032410 IDA negative regulation of transporter activity
GO:0034765 IDA regulation of ion transmembrane transport
GO:0042391 IDA regulation of membrane potential
GO:0042787 IBA protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043161 IMP proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043433 ISS negative regulation of sequence-specific DNA binding transcription factor activity
GO:0045892 ISS negative regulation of transcription, DNA-templated
GO:0046718 TAS viral entry into host cell
GO:0051224 IMP negative regulation of protein transport
GO:0051865 IDA protein autoubiquitination
GO:0070062 IDA extracellular vesicular exosome
GO:0070534 ISS protein K63-linked ubiquitination
GO:1901016 IDA regulation of potassium ion transmembrane transporter activity

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000061345 wwp2 WW domain containing E3 ubiquitin protein ligase 2 protein_coding Danio_rerio
ENSMUSG00000031930 Wwp2 WW domain containing E3 ubiquitin protein ligase 2 protein_coding Mus_musculus

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