C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: WW domain containing E3 ubiquitin protein ligase 2
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000359154 WWP2-001 ENSG00000198373 9606 + 16:69762306-69941741 protein_coding

Homo sapiens EnsemblGRCh38

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Structures from Ensembl
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Transcripts
Structures from Ensembl
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Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000359154
Transcript ID Adipose Adrenal Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000359154 4.642±0.00 6.433±0.00 5.164±4.22 4.950±3.62 2.593±1.81 1.594±1.14 3.607±3.17 2.337±1.62 3.722±1.83 5.520±0.00 6.346±4.25 6.634±3.20 7.523±0.98

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008KB CIL_0008KB_0001 VISTA 16:69347064-69947578
CIL_0001NB CIL_0001NB_0001 CGP 16:69741867-69941741

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000122 ISS negative regulation of transcription from RNA polymerase II promoter
GO:0000151 TAS ubiquitin ligase complex
GO:0001085 ISS RNA polymerase II transcription factor binding
GO:0004842 IMP:IEA ubiquitin-protein transferase activity
GO:0005515 IPI:IEA protein binding
GO:0005634 IDA nucleus
GO:0005737 IBA cytoplasm
GO:0006464 TAS cellular protein modification process
GO:0008134 IPI transcription factor binding
GO:0010629 IMP negative regulation of gene expression
GO:0016020 IDA membrane
GO:0016567 IDA protein ubiquitination
GO:0016874 IEA ligase activity
GO:0032410 IDA negative regulation of transporter activity
GO:0034765 IDA regulation of ion transmembrane transport
GO:0042391 IDA regulation of membrane potential
GO:0042787 IBA protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043161 IMP proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043433 ISS negative regulation of sequence-specific DNA binding transcription factor activity
GO:0045892 ISS negative regulation of transcription, DNA-templated
GO:0046718 TAS viral entry into host cell
GO:0051224 IMP negative regulation of protein transport
GO:0051865 IDA protein autoubiquitination
GO:0070062 IDA extracellular vesicular exosome
GO:0070534 ISS protein K63-linked ubiquitination
GO:1901016 IDA regulation of potassium ion transmembrane transporter activity

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000166615 Wwp2-201 protein_coding Mus_musculus 0 3487
ENSDART00000087364 wwp2-201 protein_coding Danio_rerio 0 1304
ENSDART00000136640 wwp2-001 protein_coding Danio_rerio 0 1304
ENSDART00000146669 wwp2-004 processed_transcript Danio_rerio 0 272

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