C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: purine nucleoside phosphorylase
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000198805 PNP 9606 + 14:20468954-20477094 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000361505 PNP-001 20469379-20477094 protein_coding
  ENST00000553418 PNP-007 20468954-20474571 protein_coding
  ENST00000553591 PNP-010 20469541-20475146 protein_coding
  ENST00000554056 PNP-005 20469414-20477058 retained_intron
  ENST00000554065 PNP-009 20470526-20474908 protein_coding
  ENST00000556293 PNP-002 20469406-20473200 retained_intron
  ENST00000556754 PNP-006 20473384-20477087 retained_intron
  ENST00000557229 PNP-003 20469406-20475163 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000361505ENST00000553418ENST00000554056ENST00000554065ENST00000556293ENST00000556754
Transcript ID Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000361505 9.551±0.00 9.103±0.00 7.491±0.00 4.170±0.00 3.769±1.38 4.230±0.00 8.353±0.00 2.310±0.00 15.161±13.62 0.745±0.42 5.605±3.78 90.371±25.90 2.388±0.00
ENST00000553418 N/A N/A N/A N/A N/A 1.110±0.00 N/A N/A N/A N/A N/A 63.277±0.00 N/A
ENST00000554056 N/A N/A N/A 1.558±0.00 N/A N/A 5.244±0.00 N/A 0.758±0.00 N/A 6.905±0.00 N/A N/A
ENST00000554065 N/A N/A N/A 4.035±0.00 N/A N/A N/A N/A N/A N/A 3.768±0.00 N/A N/A
ENST00000556293 N/A N/A N/A 1.993±0.00 1.281±0.00 N/A N/A 1.489±0.00 1.105±0.00 N/A N/A N/A N/A
ENST00000556754 N/A N/A N/A N/A N/A 0.274±0.00 N/A N/A 0.484±0.00 N/A 1.057±0.43 N/A 0.499±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0001O9 CIL_0001O9_0001 CGP 14:20457719-20477094
CIL_0002RW CIL_0002RW_0001 CGP 14:20468954-20511169

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001882 IDA nucleoside binding
GO:0002060 IDA purine nucleobase binding
GO:0003824 IEA catalytic activity
GO:0004731 IDA:IEA purine-nucleoside phosphorylase activity
GO:0005622 IDA intracellular
GO:0005737 IDA cytoplasm
GO:0005829 TAS cytosol
GO:0005856 IEA cytoskeleton
GO:0006139 IDA:IEA nucleobase-containing compound metabolic process
GO:0006144 TAS purine nucleobase metabolic process
GO:0006148 IDA inosine catabolic process
GO:0006195 TAS purine nucleotide catabolic process
GO:0006738 IDA nicotinamide riboside catabolic process
GO:0006955 IMP immune response
GO:0008144 IDA drug binding
GO:0009116 IEA nucleoside metabolic process
GO:0034356 IGI NAD biosynthesis via nicotinamide riboside salvage pathway
GO:0034418 IDA urate biosynthetic process
GO:0042102 IDA positive regulation of T cell proliferation
GO:0042301 IDA phosphate ion binding
GO:0042493 IMP response to drug
GO:0043101 TAS purine-containing compound salvage
GO:0044281 TAS small molecule metabolic process
GO:0046638 IDA positive regulation of alpha-beta T cell differentiation
GO:0055086 TAS nucleobase-containing small molecule metabolic process
GO:0070062 IDA extracellular vesicular exosome
GO:0070970 IMP interleukin-2 secretion

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000019553 pnp5b purine nucleoside phosphorylase 5b protein_coding Danio_rerio
ENSDARG00000078619 pnp5a purine nucleoside phosphorylase 5a protein_coding Danio_rerio
ENSMUSG00000021871 Pnp purine-nucleoside phosphorylase protein_coding Mus_musculus
ENSMUSG00000068417 Pnp2 purine-nucleoside phosphorylase 2 protein_coding Mus_musculus

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