C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: purine-nucleoside phosphorylase
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000021871 Pnp 10090 + 14:50944302-50965237 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000048615 Pnp-001 50944302-50953412 protein_coding
  ENSMUST00000178092 Pnp-201 50944506-50965237 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000048615ENSMUST00000178092
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000048615 4.275±0.15 1.326±0.33 3.169±0.00 0.933±0.13 3.471±0.86 1.523±0.11 0.913±0.06 3.564±0.81 7.016±1.72 3.111±0.32 0.589±0.14 2.489±1.56 7.219±1.72 0.526±0.05
ENSMUST00000178092 40.095±0.91 10.691±0.57 34.689±0.00 6.705±1.19 31.545±7.09 24.079±0.96 9.893±0.33 48.641±1.04 82.603±31.21 30.135±1.86 2.192±0.57 19.633±2.63 38.707±28.91 2.863±1.19

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0001O9 CIL_0001O9_0002 CGP 14:50926070-50965237

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001916 IMP positive regulation of T cell mediated cytotoxicity
GO:0004731 IMP purine-nucleoside phosphorylase activity
GO:0005829 IDA cytosol
GO:0006148 IMP inosine catabolic process
GO:0006149 IMP deoxyinosine catabolic process
GO:0006161 IMP deoxyguanosine catabolic process
GO:0006183 IMP GTP biosynthetic process
GO:0008630 IMP intrinsic apoptotic signaling pathway in response to DNA damage
GO:0008637 IMP apoptotic mitochondrial changes
GO:0010332 IMP response to gamma radiation
GO:0034418 IMP urate biosynthetic process
GO:0042102 IMP positive regulation of T cell proliferation
GO:0042278 IDA purine nucleoside metabolic process
GO:0045579 IMP positive regulation of B cell differentiation
GO:0045739 IMP positive regulation of DNA repair
GO:0046070 IMP dGTP metabolic process
GO:0046115 IMP guanosine catabolic process
GO:0046638 IMP positive regulation of alpha-beta T cell differentiation
GO:0070233 IMP negative regulation of T cell apoptotic process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000019553 pnp5b purine nucleoside phosphorylase 5b protein_coding Danio_rerio
ENSDARG00000078619 pnp5a purine nucleoside phosphorylase 5a protein_coding Danio_rerio
ENSG00000198805 PNP purine nucleoside phosphorylase protein_coding Homo_sapiens

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