C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: G protein-coupled receptor kinase 5
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000198873 GRK5 9606 + 10:119207589-119459742 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000369108 GRK5-003 119452448-119459742 retained_intron
  ENST00000392870 GRK5-002 119207589-119455619 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000369108ENST00000392870
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000369108 N/A N/A N/A N/A N/A N/A N/A N/A 0.180±0.00 N/A 0.264±0.00 1.490±0.00 N/A N/A
ENST00000392870 10.963±0.00 13.819±0.00 0.351±0.00 2.142±1.23 7.784±3.62 14.892±13.35 6.426±4.64 2.749±1.72 2.961±0.70 34.948±32.76 2.626±1.94 16.069±9.38 10.387±1.23 5.833±3.15

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0005VT CIL_0005VT_0001 CGP 10:119167703-119459742

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004672 IEA protein kinase activity
GO:0004674 IDA:IEA protein serine/threonine kinase activity
GO:0004703 IEA G-protein coupled receptor kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005080 TAS protein kinase C binding
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005543 TAS phospholipid binding
GO:0005634 IEA nucleus
GO:0005737 IEA cytoplasm
GO:0005886 IDA plasma membrane
GO:0006468 IEA protein phosphorylation
GO:0006915 IEA apoptotic process
GO:0007188 TAS adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0007217 IDA tachykinin receptor signaling pathway
GO:0008277 TAS:IEA regulation of G-protein coupled receptor protein signaling pathway
GO:0016055 IEA Wnt signaling pathway
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0038032 IEA termination of G-protein coupled receptor signaling pathway
GO:0043066 IDA negative regulation of apoptotic process
GO:0046777 IDA protein autophosphorylation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000078815 grk5l G protein-coupled receptor kinase 5 like protein_coding Danio_rerio
ENSMUSG00000003228 Grk5 G protein-coupled receptor kinase 5 protein_coding Mus_musculus

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