C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: major histocompatibility complex, class II, DR alpha
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000204287 HLA-DRA 9606 + 6:32439842-32445046 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000374982 HLA-DRA-002 32439878-32445046 protein_coding
  ENST00000395388 HLA-DRA-001 32439842-32445046 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000374982ENST00000395388
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000374982 13.563±0.00 117.425±0.00 N/A 13.014±0.00 35.002±0.00 N/A 7.297±4.91 N/A 4.144±0.00 312.410±0.00 6.277±2.55 37.382±0.00 63.017±0.00 10.323±1.99
ENST00000395388 99.401±0.00 480.583±0.00 18.623±0.00 50.186±41.23 111.751±36.72 51.385±7.89 44.756±28.87 130.270±76.57 31.405±14.81 546.621±301.67 21.530±7.80 104.238±60.47 140.523±56.13 50.414±30.91

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0001PL CIL_0001PL_0007 CGP 6:32439842-32530287

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000139 TAS Golgi membrane
GO:0002503 IDA peptide antigen assembly with MHC class II protein complex
GO:0002504 IEA antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
GO:0002506 IDA polysaccharide assembly with MHC class II protein complex
GO:0005515 IEA protein binding
GO:0005764 IDA lysosome
GO:0005765 IDA lysosomal membrane
GO:0005886 IDA plasma membrane
GO:0005887 NAS integral component of plasma membrane
GO:0006955 IEA immune response
GO:0009986 IDA cell surface
GO:0012507 TAS ER to Golgi transport vesicle membrane
GO:0016020 IEA membrane
GO:0016021 IEA integral component of membrane
GO:0019221 TAS cytokine-mediated signaling pathway
GO:0019882 IEA antigen processing and presentation
GO:0019886 TAS antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0023026 IDA MHC class II protein complex binding
GO:0030658 TAS transport vesicle membrane
GO:0030666 TAS endocytic vesicle membrane
GO:0030669 TAS clathrin-coated endocytic vesicle membrane
GO:0031295 TAS T cell costimulation
GO:0031902 IDA late endosome membrane
GO:0032395 NAS MHC class II receptor activity
GO:0032588 TAS trans-Golgi network membrane
GO:0042605 IDA peptide antigen binding
GO:0042613 IEA MHC class II protein complex
GO:0050852 TAS T cell receptor signaling pathway
GO:0050890 IMP cognition
GO:0060333 TAS interferon-gamma-mediated signaling pathway
GO:0070062 IDA extracellular vesicular exosome
GO:0071556 TAS integral component of lumenal side of endoplasmic reticulum membrane

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000001832 si:ch1073-403i13.1 si:ch1073-403i13.1 protein_coding Danio_rerio
ENSDARG00000020286 zgc:123107 zgc:123107 protein_coding Danio_rerio
ENSDARG00000031745 si:busm1-266f07.2 si:busm1-266f07.2 protein_coding Danio_rerio
ENSDARG00000053739 si:busm1-160c18.1 si:busm1-160c18.1 protein_coding Danio_rerio
ENSDARG00000055441 si:busm1-48c11.3 si:busm1-48c11.3 protein_coding Danio_rerio
ENSDARG00000070206 si:zfos-2070c2.1 si:zfos-2070c2.1 protein_coding Danio_rerio
ENSDARG00000074816 si:zfos-367g9.1 si:zfos-367g9.1 protein_coding Danio_rerio
ENSDARG00000075932 si:ch73-211l2.3 si:ch73-211l2.3 protein_coding Danio_rerio
ENSDARG00000079593 si:busm1-228j01.5 si:busm1-228j01.5 protein_coding Danio_rerio
ENSDARG00000086294 CU914776.1 Uncharacterized protein protein_coding Danio_rerio

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