C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: lecithin-cholesterol acyltransferase
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000213398 LCAT 9606 - 16:67939750-67944131 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000264005 LCAT-001 67939750-67944131 protein_coding
  ENST00000570369 LCAT-008 67939882-67943094 protein_coding
  ENST00000570396 LCAT-012 67941817-67942458 protein_coding
  ENST00000570980 LCAT-004 67940246-67943625 protein_coding
  ENST00000573538 LCAT-007 67939882-67942930 nonsense_mediated_decay
  ENST00000573846 LCAT-006 67942157-67942901 retained_intron
  ENST00000575277 LCAT-005 67942399-67943144 retained_intron
  ENST00000575467 LCAT-003 67941368-67944131 nonsense_mediated_decay
  ENST00000576450 LCAT-011 67941809-67942577 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; KidneyLiverOvaryENST00000264005ENST00000570396ENST00000573538ENST00000575277
Transcript ID Kidney Liver Ovary
ENST00000264005 28.805±0.00 40.617±0.00 N/A
ENST00000570396 58.402±0.00 N/A N/A
ENST00000573538 N/A 20.889±0.00 N/A
ENST00000575277 N/A N/A 2.605±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_000030 CIL_000030_0001 CGP 16:67934502-67944131
CIL_00003H CIL_00003H_0001 CGP 16:67939750-67969601

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004607 IDA phosphatidylcholine-sterol O-acyltransferase activity
GO:0005515 IPI protein binding
GO:0005576 TAS extracellular region
GO:0005615 IDA extracellular space
GO:0006629 IEA lipid metabolic process
GO:0006644 IDA phospholipid metabolic process
GO:0006656 IDA phosphatidylcholine biosynthetic process
GO:0008203 IDA cholesterol metabolic process
GO:0008374 IEA O-acyltransferase activity
GO:0030301 IDA cholesterol transport
GO:0034186 IPI apolipoprotein A-I binding
GO:0034364 IDA high-density lipoprotein particle
GO:0034372 IDA very-low-density lipoprotein particle remodeling
GO:0034375 IDA high-density lipoprotein particle remodeling
GO:0034435 IDA cholesterol esterification
GO:0042157 TAS lipoprotein metabolic process
GO:0042158 IEA lipoprotein biosynthetic process
GO:0042632 IDA cholesterol homeostasis
GO:0043691 IDA reverse cholesterol transport
GO:0044281 TAS small molecule metabolic process
GO:0070062 IDA extracellular vesicular exosome
GO:0090107 IEA regulation of high-density lipoprotein particle assembly

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000062375 lcat lecithin-cholesterol acyltransferase protein_coding Danio_rerio
ENSMUSG00000035237 Lcat lecithin cholesterol acyltransferase protein_coding Mus_musculus

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