C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: major histocompatibility complex, class II, DP beta 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000223865 HLA-DPB1 9606 + 6:33075926-33087201 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000416804 HLA-DPB1-002 33080672-33087201 protein_coding
  ENST00000418931 HLA-DPB1-001 33075926-33087201 protein_coding
  ENST00000428835 HLA-DPB1-008 33080487-33085889 protein_coding
  ENST00000469120 HLA-DPB1-004 33076010-33081232 retained_intron
  ENST00000471184 HLA-DPB1-006 33080386-33084012 processed_transcript
  ENST00000478189 HLA-DPB1-009 33080941-33083890 processed_transcript
  ENST00000488575 HLA-DPB1-005 33080386-33084957 processed_transcript
  ENST00000498038 HLA-DPB1-007 33080443-33085231 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000416804ENST00000418931ENST00000428835ENST00000488575
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000416804 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 1.994±0.00 N/A N/A N/A
ENST00000418931 35.433±0.00 173.370±0.00 6.476±0.00 8.435±6.43 37.670±22.90 11.915±7.47 9.862±5.62 16.045±7.37 6.425±3.60 48.926±0.00 3.129±0.00 21.239±18.47 13.836±0.00 11.384±7.24
ENST00000428835 81.863±0.00 N/A 9.799±0.00 3.250±0.00 25.079±0.00 23.923±6.13 5.412±0.00 60.739±0.00 12.212±3.58 44.360±0.00 10.020±3.42 10.256±0.00 N/A 43.278±0.00
ENST00000488575 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 10.795±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0001PI CIL_0001PI_0002 CGP 6:33004178-33080775
CIL_0001PL CIL_0001PL_0008 CGP 6:33064569-33087201

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000139 TAS Golgi membrane
GO:0002504 IEA antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
GO:0005515 IEA protein binding
GO:0005765 TAS lysosomal membrane
GO:0005768 IEA endosome
GO:0005886 TAS plasma membrane
GO:0006955 IEA immune response
GO:0009986 IMP cell surface
GO:0012507 TAS ER to Golgi transport vesicle membrane
GO:0016020 IEA membrane
GO:0016021 IEA integral component of membrane
GO:0019221 TAS cytokine-mediated signaling pathway
GO:0019882 IEA antigen processing and presentation
GO:0019886 IMP antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0030658 TAS transport vesicle membrane
GO:0030666 TAS endocytic vesicle membrane
GO:0030669 TAS clathrin-coated endocytic vesicle membrane
GO:0031295 TAS T cell costimulation
GO:0032588 TAS trans-Golgi network membrane
GO:0032729 IMP positive regulation of interferon-gamma production
GO:0042102 IMP positive regulation of T cell proliferation
GO:0042605 IDA peptide antigen binding
GO:0042613 IEA MHC class II protein complex
GO:0050852 TAS T cell receptor signaling pathway
GO:0050870 IMP positive regulation of T cell activation
GO:0060333 TAS interferon-gamma-mediated signaling pathway
GO:0071556 TAS integral component of lumenal side of endoplasmic reticulum membrane

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000041705 si:busm1-228j01.6 si:busm1-228j01.6 protein_coding Danio_rerio
ENSDARG00000053738 si:dkey-33b17.3 si:dkey-33b17.3 protein_coding Danio_rerio
ENSDARG00000054921 wu:fd58b11 wu:fd58b11 protein_coding Danio_rerio
ENSDARG00000055447 si:busm1-194e12.12 si:busm1-194e12.12 protein_coding Danio_rerio
ENSDARG00000056330 mhc2dbb major histocompatibility complex class II DBB gene protein_coding Danio_rerio
ENSDARG00000074510 si:busm1-104n07.3 si:busm1-104n07.3 protein_coding Danio_rerio
ENSDARG00000076307 si:zfos-2070c2.3 si:zfos-2070c2.3 protein_coding Danio_rerio
ENSDARG00000079105 mhc2dab major histocompatibility complex class II DAB gene protein_coding Danio_rerio
ENSDARG00000088872 si:busm1-228j01.4 si:busm1-228j01.4 protein_coding Danio_rerio
ENSDARG00000093706 si:dkey-33b17.3 si:dkey-33b17.3 protein_coding Danio_rerio

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